2,6-anhydro-1,3,5-tri-O-benzyl-7-(O6-benzylguanin-8-yl)-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-7-deoxy-D-glycero-D-manno-heptitol

Base Information

Chemical Name:2,6-anhydro-1,3,5-tri-O-benzyl-7-(O6-benzylguanin-8-yl)-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-7-deoxy-D-glycero-D-manno-heptitol
CAS No.:1311277-70-9
Molecular Formula:C₅₅H₅₇N₅O₁₁
Molecular Weight:964.084
Hs Code.:

2,6-anhydro-1,3,5-tri-O-benzyl-7-(O6-benzylguanin-8-yl)-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-7-deoxy-D-glycero-D-manno-heptitol

Synonyms:2,6-anhydro-1,3,5-tri-O-benzyl-7-(O6-benzylguanin-8-yl)-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-7-deoxy-D-glycero-D-manno-heptitol

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Chemical Property of 2,6-anhydro-1,3,5-tri-O-benzyl-7-(O6-benzylguanin-8-yl)-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-7-deoxy-D-glycero-D-manno-heptitol

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Technology Process of 2,6-anhydro-1,3,5-tri-O-benzyl-7-(O6-benzylguanin-8-yl)-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-7-deoxy-D-glycero-D-manno-heptitol

There total 13 articles about 2,6-anhydro-1,3,5-tri-O-benzyl-7-(O6-benzylguanin-8-yl)-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-7-deoxy-D-glycero-D-manno-heptitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311277-69-6
3,7-anhydro-N-(2-amino-6-benzyloxy-5-nitrosopyrimidin-4-yl)-4,6,8-tri-O-benzyl-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-2-deoxy-D-glycero-D-talo-octonamide

: 1311277-70-9
2,6-anhydro-1,3,5-tri-O-benzyl-7-(O6-benzylguanin-8-yl)-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-7-deoxy-D-glycero-D-manno-heptitol

Guidance literature:: With 1,2-bis-(diphenylphosphino)ethane; In para-xylene; at 80 ℃; for 4h; Inert atmosphere; Reflux;
DOI:10.1016/j.tetlet.2011.02.102

Reference yield:

: 1311277-67-4
3,7-anhydro-4,6,8-tri-O-benzyl-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-2-deoxy-D-glycero-α-D-talo-octonic acid

: 1311277-70-9
2,6-anhydro-1,3,5-tri-O-benzyl-7-(O6-benzylguanin-8-yl)-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-7-deoxy-D-glycero-D-manno-heptitol

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3.5 h / Inert atmosphere

2: potassium carbonate / tetrahydrofuran / -30 - 25 °C / Inert atmosphere

3: 1,2-bis-(diphenylphosphino)ethane / para-xylene / 4 h / 80 °C / Inert atmosphere; Reflux

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; dichloromethane; para-xylene;
DOI:10.1016/j.tetlet.2011.02.102

Reference yield:

: 1311277-66-3
2,6-anhydro-1,3,5-tri-O-benzyl-4-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-7,8,9-trideoxy-D-glycero-D-manno-non-8-enitol

: 1311277-70-9
2,6-anhydro-1,3,5-tri-O-benzyl-7-(O6-benzylguanin-8-yl)-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-7-deoxy-D-glycero-D-manno-heptitol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 25 °C / Inert atmosphere

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3.5 h / Inert atmosphere

3: potassium carbonate / tetrahydrofuran / -30 - 25 °C / Inert atmosphere

4: 1,2-bis-(diphenylphosphino)ethane / para-xylene / 4 h / 80 °C / Inert atmosphere; Reflux

With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; dichloromethane; para-xylene; water; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2011.02.102