2-(4-tert-butylphenyl)-5-[4-(2,5-dibromothiophen-3-yl)phenyl]-1,3,4-oxadiazole

Base Information

Chemical Name:2-(4-tert-butylphenyl)-5-[4-(2,5-dibromothiophen-3-yl)phenyl]-1,3,4-oxadiazole
CAS No.:1237493-75-2
Molecular Formula:C₂₂H₁₈Br₂N₂OS
Molecular Weight:518.272
Hs Code.:

Synonyms:2-(4-tert-butylphenyl)-5-[4-(2,5-dibromothiophen-3-yl)phenyl]-1,3,4-oxadiazole

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Chemical Property of 2-(4-tert-butylphenyl)-5-[4-(2,5-dibromothiophen-3-yl)phenyl]-1,3,4-oxadiazole

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Technology Process of 2-(4-tert-butylphenyl)-5-[4-(2,5-dibromothiophen-3-yl)phenyl]-1,3,4-oxadiazole

There total 4 articles about 2-(4-tert-butylphenyl)-5-[4-(2,5-dibromothiophen-3-yl)phenyl]-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1237493-74-1
2-(4-tert-butylphenyl)-5-[4-(thiophen-3-yl)phenyl]-1,3,4-oxadiazole

: 1237493-75-2
2-(4-tert-butylphenyl)-5-[4-(2,5-dibromothiophen-3-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: With N-Bromosuccinimide; acetic acid; In tetrahydrofuran; at 80 ℃; for 6h;
DOI:10.1002/pola.24117

Reference yield:

: 623-00-7
4-bromobenzenecarbonitrile

: 1237493-75-2
2-(4-tert-butylphenyl)-5-[4-(2,5-dibromothiophen-3-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere

2: pyridine / 6 h / 130 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; toluene / 90 °C / Inert atmosphere

4: N-Bromosuccinimide; acetic acid / tetrahydrofuran / 6 h / 80 °C

With pyridine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; potassium carbonate; ammonium chloride; acetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; 3: Suzuki coupling;
DOI:10.1002/pola.24117

Reference yield:

: 220843-12-9
2-(4-bromophenyl)-5-(4-(tert-butyl)phenyl)-1,3,4-oxadiazole

: 1237493-75-2
2-(4-tert-butylphenyl)-5-[4-(2,5-dibromothiophen-3-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; toluene / 90 °C / Inert atmosphere

2: N-Bromosuccinimide; acetic acid / tetrahydrofuran / 6 h / 80 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; In tetrahydrofuran; water; toluene; 1: Suzuki coupling;
DOI:10.1002/pola.24117