(2R)-N-hydroxy-2-methyl-4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)butanamide

Base Information

Chemical Name:(2R)-N-hydroxy-2-methyl-4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)butanamide
CAS No.:1402636-22-9
Molecular Formula:C₁₆H₂₁N₃O₄S
Molecular Weight:351.426
Hs Code.:

Synonyms:(2R)-N-hydroxy-2-methyl-4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-N-hydroxy-2-methyl-4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)butanamide

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Technology Process of (2R)-N-hydroxy-2-methyl-4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)butanamide

There total 5 articles about (2R)-N-hydroxy-2-methyl-4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1402636-25-2
(2R)-2-methyl-4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

: 1402636-22-9
(2R)-N-hydroxy-2-methyl-4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)butanamide

Guidance literature:: With ethanol; pyridinium p-toluenesulfonate; In ethanol; for 3h; Reflux;

Reference yield:

: 1312478-47-9
ethyl (±)-4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1402636-22-9
(2R)-N-hydroxy-2-methyl-4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: MCC-2 / ethanol / Resolution of racemate

2.1: caesium carbonate / tetrahydrofuran / 70 °C

3.1: potassium hydroxide; water / tetrahydrofuran; methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 20 °C

5.1: ethanol / pyridinium p-toluenesulfonate / ethanol / 3 h / Reflux

With ethanol; water; benzotriazol-1-ol; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 1312478-48-0
(2R)-ethyl 4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1402636-22-9
(2R)-N-hydroxy-2-methyl-4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tetrahydrofuran / 70 °C

2.1: potassium hydroxide; water / tetrahydrofuran; methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C

4.1: ethanol / pyridinium p-toluenesulfonate / ethanol / 3 h / Reflux

With ethanol; water; benzotriazol-1-ol; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; ethanol; dichloromethane;