(3RS)-2-benzyloxycarbonyl-1,2,3,4-tetrahydro-3-(1H-tetrazol-5-yl)-β-carboline

Base Information

Chemical Name:(3RS)-2-benzyloxycarbonyl-1,2,3,4-tetrahydro-3-(1H-tetrazol-5-yl)-β-carboline
CAS No.:98667-28-8
Molecular Formula:C₂₀H₁₈N₆O₂
Molecular Weight:374.402
Hs Code.:

Synonyms:(3RS)-2-benzyloxycarbonyl-1,2,3,4-tetrahydro-3-(1H-tetrazol-5-yl)-β-carboline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3RS)-2-benzyloxycarbonyl-1,2,3,4-tetrahydro-3-(1H-tetrazol-5-yl)-β-carboline

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Technology Process of (3RS)-2-benzyloxycarbonyl-1,2,3,4-tetrahydro-3-(1H-tetrazol-5-yl)-β-carboline

There total 4 articles about (3RS)-2-benzyloxycarbonyl-1,2,3,4-tetrahydro-3-(1H-tetrazol-5-yl)-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 98667-27-7
(3RS)-2-benzyloxycarbonyl-3-cyano-1,2,3,4-tetrahydro-β-carboline

: 98667-28-8
(3RS)-2-benzyloxycarbonyl-1,2,3,4-tetrahydro-3-(1H-tetrazol-5-yl)-β-carboline

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 95 - 100 ℃; for 6h;
DOI:10.1248/cpb.35.3284

Reference yield:

: ammonium chloride

: 98667-27-7
(3RS)-2-benzyloxycarbonyl-3-cyano-1,2,3,4-tetrahydro-β-carboline

: 98667-28-8
(3RS)-2-benzyloxycarbonyl-1,2,3,4-tetrahydro-3-(1H-tetrazol-5-yl)-β-carboline

Guidance literature:: With sodium azide; In N-methyl-acetamide;

Reference yield:

: 98718-63-9
(3RS)-2-Benzyloxycarbonyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid

: 98667-28-8
(3RS)-2-benzyloxycarbonyl-1,2,3,4-tetrahydro-3-(1H-tetrazol-5-yl)-β-carboline

Guidance literature:: Multi-step reaction with 3 steps

1: ethyl chloroformate, Et₃N; 2.) 28percent NH₄OH / 1.) THF, -10 deg C, 40 min; 2.) H₂O, 0 deg C, 3 h

2: 82 percent / POCl₃, pyridine / 2 h / Ambient temperature

3: 48 percent / NaN₃, NH₄Cl / dimethylformamide / 6 h / 95 - 100 °C

With pyridine; ammonium hydroxide; sodium azide; chloroformic acid ethyl ester; ammonium chloride; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.3284