(S,2Z,4E)-ethyl 5-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

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Chemical Name:(S,2Z,4E)-ethyl 5-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate
CAS No.:932406-30-9
Molecular Formula:C₃₂H₃₈N₂O₅S
Molecular Weight:562.73
Hs Code.:

Synonyms:(S,2Z,4E)-ethyl 5-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

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Chemical Property of (S,2Z,4E)-ethyl 5-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

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Technology Process of (S,2Z,4E)-ethyl 5-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

There total 2 articles about (S,2Z,4E)-ethyl 5-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 932406-29-6
(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate

: 107905-52-2
ethyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate

: 932406-30-9
(S,2Z,4E)-ethyl 5-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Guidance literature:: ethyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate; With 18-crown-6 ether; potassium hexamethylsilazane; In dichloromethane; at -78 ℃;

(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate; In dichloromethane; at -78 ℃; for 4h; optical yield given as %de;
DOI:10.1016/j.tet.2010.05.040

Reference yield:

: 932406-29-6
(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate

: 107905-52-2
ethyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate

: (S,2E,4E)-ethyl 5-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

: 932406-30-9
(S,2Z,4E)-ethyl 5-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In toluene; at -20 ℃; optical yield given as %de;
DOI:10.1016/j.tet.2010.05.040

Reference yield:

: 932406-30-9
(S,2Z,4E)-ethyl 5-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

: 932406-31-0
C₂₇H₃₀N₂O₃S

Guidance literature:: (S,2Z,4E)-ethyl 5-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate; With trifluoroacetic acid; In dichloromethane; at 0 ℃;

With sodium hydrogencarbonate; In water;
DOI:10.1016/j.tet.2010.05.040