(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate

Base Information

Chemical Name:(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate
CAS No.:932406-29-6
Molecular Formula:C₂₇H₃₀N₂O₄S
Molecular Weight:478.612
Hs Code.:

Synonyms:(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate

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Chemical Property of (S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate

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Technology Process of (S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate

There total 9 articles about (S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 932406-28-5
(S)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-formylthiazol-2-yl)ethylcarbamate

: 24720-64-7
2-(triphenylphosphoranylidene)propionaldehyde

: 932406-29-6
(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate

Guidance literature:: In benzene; for 5h; Heating;
DOI:10.1016/j.tetlet.2007.01.034

Reference yield:

: (S)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-hydroxymethylthiazol-2-yl)ethylcarbamate

: 932406-29-6
(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 123 mg / MnO₂ / CH₂Cl₂ / 20 h / 20 °C

2: 92 percent / benzene / 5 h / Heating

With manganese(IV) oxide; In dichloromethane; benzene; 2: Wittig reaction;
DOI:10.1016/j.tetlet.2007.01.034

Reference yield:

: 932406-25-2
(S)-methyl 2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)-4,5-dihydrooxazole-4-carboxylate

: 932406-29-6
(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 92 percent / H₂S; Et₃N / methanol / 20 °C

2.1: diethylaminosulfur trifluoride / CH₂Cl₂ / 0.5 h / -78 °C

2.2: 80 percent / DBU; BrCCl₃ / CH₂Cl₂ / -40 - 20 °C

3.1: LiAlH₄ / diethyl ether / 0 - 20 °C

4.1: 123 mg / MnO₂ / CH₂Cl₂ / 20 h / 20 °C

5.1: 92 percent / benzene / 5 h / Heating

With manganese(IV) oxide; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; hydrogen sulfide; triethylamine; In methanol; diethyl ether; dichloromethane; benzene; 5.1: Wittig reaction;
DOI:10.1016/j.tetlet.2007.01.034