tert-butyl (3R)-6-cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]hexanoate

Base Information

Chemical Name:tert-butyl (3R)-6-cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]hexanoate
CAS No.:467434-26-0
Molecular Formula:C₂₅H₃₄FN₃O₆S
Molecular Weight:523.626
Hs Code.:

Synonyms:tert-butyl (3R)-6-cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]hexanoate

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Chemical Property of tert-butyl (3R)-6-cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]hexanoate

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Technology Process of tert-butyl (3R)-6-cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]hexanoate

There total 1 articles about tert-butyl (3R)-6-cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348623-01-8
W⁽⁰¹⁰⁾O_2047901

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 467434-26-0
tert-butyl (3R)-6-cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]hexanoate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm061010z

Reference yield:

: 467434-26-0
tert-butyl (3R)-6-cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]hexanoate

: 467434-27-1
(3R)-6-cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]hexanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm061010z

Reference yield:

: 467434-26-0
tert-butyl (3R)-6-cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]hexanoate

: (3R)-6-Cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0.40 g / trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

2.1: iso-butylchloroformate; Et₃N / tetrahydrofuran / 1 h / 0 °C

2.2: O-trimethylsilyl hydroxylamine / tetrahydrofuran / 20 °C

2.3: 0.17 g / MeOH / tetrahydrofuran / 1.5 h

With triethylamine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm061010z