2'-tert-butyldimethylsilyl-4-deacetyl-7-(triethylsilyl)paclitaxel

Base Information

• Chemical Name: 2'-tert-butyldimethylsilyl-4-deacetyl-7-(triethylsilyl)paclitaxel
• CAS No.: 160768-76-3
• Molecular Formula: C₅₇H₇₇NO₁₃Si₂
• Molecular Weight: 1040.41
• Mol file: 160768-76-3.mol

Synonyms:2'-tert-butyldimethylsilyl-4-deacetyl-7-(triethylsilyl)paclitaxel

Chemical Property of 2'-tert-butyldimethylsilyl-4-deacetyl-7-(triethylsilyl)paclitaxel

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-tert-butyldimethylsilyl-4-deacetyl-7-(triethylsilyl)paclitaxel

There total 6 articles about 2'-tert-butyldimethylsilyl-4-deacetyl-7-(triethylsilyl)paclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

benzoic acid (65-85-0,8013-63-6) + 2'-O-(tert-butyldimethylsilyl)-4-O-deacetyl-2-O-debenzoyl-7-O-(triethylsilyl)paclitaxel (160768-75-2) → 2'-tert-butyldimethylsilyl-4-deacetyl-7-(triethylsilyl)paclitaxel (160768-76-3)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In toluene;

DOI:10.1016/0040-4039(94)85018-6

Reference yield:

triethylsilyl chloride (994-30-9) → 2'-tert-butyldimethylsilyl-4-deacetyl-7-(triethylsilyl)paclitaxel (160768-76-3)

Guidance literature:

Multi-step reaction with 3 steps

1: imidazole

2: 69 percent / benzyltrimethylammonium methoxide / CH₂Cl₂

3: 67 percent / DCC, DMAP / toluene

With 1H-imidazole; dmap; benzyltrismethylammonium methoxide; dicyclohexyl-carbodiimide; In dichloromethane; toluene;

DOI:10.1016/0040-4039(94)85018-6

Reference yield:

taxol (33069-62-4) → 2'-tert-butyldimethylsilyl-4-deacetyl-7-(triethylsilyl)paclitaxel (160768-76-3)

Guidance literature:

Multi-step reaction with 4 steps

1: imidazole

2: imidazole

3: 69 percent / benzyltrimethylammonium methoxide / CH₂Cl₂

4: 67 percent / DCC, DMAP / toluene

With 1H-imidazole; dmap; benzyltrismethylammonium methoxide; dicyclohexyl-carbodiimide; In dichloromethane; toluene;

DOI:10.1016/0040-4039(94)85018-6

upstream raw materials:

benzoic acid

2'-O-(tert-butyldimethylsilyl)-4-O-deacetyl-2-O-debenzoyl-7-O-(triethylsilyl)paclitaxel

triethylsilyl chloride

taxol