(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucine ester

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Chemical Name:(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucine ester
CAS No.:196950-36-4
Molecular Formula:C₃₅H₅₄N₆O₁₁
Molecular Weight:734.847
Hs Code.:

Synonyms:(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucine ester

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Chemical Property of (2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucine ester

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Technology Process of (2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucine ester

There total 12 articles about (2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucine ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 196950-33-1
Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucinate diester

: 196950-36-4
(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucine ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 18h;
DOI:10.1039/a702410j

Reference yield:

: 118700-84-8
(S)-3-(2-(tert-butoxycarbonylamino)-3-phenyl-propanamido)propanoic acid

: 196950-36-4
(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucine ester

Guidance literature:: Multi-step reaction with 9 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

3: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

4: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

5: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

6: 95 percent / H₂ / 5percent Pd/C / methanol / 12 h

7: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

8: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

9: 82 percent / H₂ / 5percent Pd/C / methanol / 18 h

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1039/a702410j

Reference yield:

: 110473-10-4
N-Boc-D-Glu α-methyl ester

: 196950-36-4
(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucine ester

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / HCl / ethyl acetate / 1 h / 0 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

3: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

4: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

5: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

6: 95 percent / H₂ / 5percent Pd/C / methanol / 12 h

7: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

8: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

9: 82 percent / H₂ / 5percent Pd/C / methanol / 18 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; ethyl acetate;
DOI:10.1039/a702410j