Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucinate diester

Base Information

• Chemical Name: Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucinate diester
• CAS No.: 196950-33-1
• Molecular Formula: C₄₂H₆₀N₆O₁₁
• Molecular Weight: 824.972

Synonyms:Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucinate diester

Chemical Property of Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucinate diester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucinate diester

There total 10 articles about Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucinate diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-(2-(tert-butoxycarbonylamino)-3-phenyl-propanamido)propanoic acid (118700-84-8) → Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucinate diester (196950-33-1)

Guidance literature:

Multi-step reaction with 8 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

3: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

4: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

5: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

6: 95 percent / H₂ / 5percent Pd/C / methanol / 12 h

7: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

8: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;

DOI:10.1039/a702410j

Reference yield:

N-Boc-D-Glu α-methyl ester (110473-10-4) → Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucinate diester (196950-33-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 93 percent / HCl / ethyl acetate / 1 h / 0 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

3: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

4: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

5: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

6: 95 percent / H₂ / 5percent Pd/C / methanol / 12 h

7: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

8: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; ethyl acetate;

DOI:10.1039/a702410j

Reference yield:

C22H32N2O7 (1026326-12-4) → Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucinate diester (196950-33-1)

Guidance literature:

Multi-step reaction with 7 steps

1: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

2: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

3: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

4: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

5: 95 percent / H₂ / 5percent Pd/C / methanol / 12 h

6: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

7: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;

DOI:10.1039/a702410j

upstream raw materials:

(R)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-[(2-isobutoxycarbonyloxy-2-oxo-ethyl)-methyl-carbamoyl]-butyric acid methyl ester

(S)-3-(2-(tert-butoxycarbonylamino)-3-phenyl-propanamido)propanoic acid

N-Boc-D-Glu α-methyl ester

Benzyl (2R)-N-(tert-butoxycarbonyl)alanyl-(2S)-leucinate

Downstream raw materials:

β-Pentafluorophenyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucyl-(α-methyl (2R)aspartate) triester

β-Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucyl-(α-methyl (2R)aspartate) triester

(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucyl-(α-methyl (2R)aspartate) diester

(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucine ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 196950-33-1 Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(2R)-alanyl-(2S)-leucinate diester

Send

Send

Metric Ton KG G Pound L ML

Send

Send