Omeprazole Sulfone N-Oxide

Base Information

• Chemical Name: Omeprazole Sulfone N-Oxide
• CAS No.: 158812-85-2
• Molecular Formula: C₁₇H₁₉N₃O₅S
• Molecular Weight: 377.421
• Hs Code.: 2933399090
• Mol file: 158812-85-2.mol

Synonyms:1H-Benzimidazole,5-methoxy-2-[[(4-methoxy-3,5-dimethyl-1-oxido-2-pyridinyl)methyl]sulfonyl]-(9CI); 1H-Benzimidazole,5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-, N-oxide

Chemical Property of Omeprazole Sulfone N-Oxide

Chemical Property:

• Vapor Pressure: 3.95E-19mmHg at 25°C
• Melting Point: 200-202°C
• Refractive Index: 1.635
• Boiling Point: 694.4°C at 760 mmHg
• PKA: 8.14±0.10(Predicted)
• Flash Point: 373.7°C
• PSA: 115.12000
• Density: 1.40±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: 3.68010
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

Omeprazole Sulfone N-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Omeprazole Sulfone N-Oxide (Omeprazole EP Impurity I) is a metabolite of Omeprazole. Impurity I. A metabolite of Omeprazole. Impurity I

Technology Process of Omeprazole Sulfone N-Oxide

There total 3 articles about Omeprazole Sulfone N-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

C17H19N3O3S → omeprazole sulfone (88546-55-8) + C17H19N3O5S (158812-85-2)

Guidance literature:

With sodium chlorate; at 2 - 8 ℃; for 2h; Temperature;

Reference yield:

omeprazole (73590-58-6,326602-80-6) → C17H19N3O5S (158812-85-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/c9nj00932a

Reference yield:

omeprazole (73590-58-6,326602-80-6) → C17H19N3O5S (158812-85-2) + C17H19N3O4S (176219-04-8) + C16H17N3O2

Guidance literature:

With dihydrogen peroxide; In water; at 20 ℃; for 24h;

DOI:10.1039/c9nj00932a

upstream raw materials:

omeprazole