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Omeprazole

Base Information Edit
  • Chemical Name:Omeprazole
  • CAS No.:73590-58-6
  • Deprecated CAS:172964-80-6,131959-78-9,131959-78-9
  • Molecular Formula:C17H19N3O3S
  • Molecular Weight:345.422
  • Hs Code.:29333990
  • European Community (EC) Number:615-996-8,620-470-6,623-285-9
  • NSC Number:759192,751450
  • UNII:KG60484QX9
  • DSSTox Substance ID:DTXSID6021080
  • Nikkaji Number:J33.884B
  • Wikipedia:Omeprazole
  • Wikidata:Q422210
  • NCI Thesaurus Code:C74598,C65538,C65539,C66256,C716
  • RXCUI:7646,236486,283742,1294569,1792108
  • Pharos Ligand ID:32ATJZBGT8TF
  • Metabolomics Workbench ID:145082
  • ChEMBL ID:CHEMBL1503
  • Mol file:73590-58-6.mol
Omeprazole

Synonyms:H 168 68;H 168-68;H 16868;Magnesium, Omeprazole;Omeprazole;Omeprazole Magnesium;Omeprazole Sodium;Prilosec;Sodium, Omeprazole

Suppliers and Price of Omeprazole
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Omeprazole
  • 50mg
  • $ 55.00
  • Tocris
  • Omeprazole ≥99%(HPLC)
  • 50
  • $ 83.00
  • TCI Chemical
  • Omeprazole >98.0%(HPLC)(T)
  • 25g
  • $ 287.00
  • TCI Chemical
  • Omeprazole >98.0%(HPLC)(T)
  • 5g
  • $ 83.00
  • Sigma-Aldrich
  • Omeprazole solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • 1 mL
  • $ 52.40
  • Sigma-Aldrich
  • Omeprazole solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
  • 021-1ml
  • $ 50.80
  • Sigma-Aldrich
  • Omeprazole Pharmaceutical Secondary Standard; Certified Reference Material
  • 1g
  • $ 80.10
  • Sigma-Aldrich
  • Omeprazole solid
  • 100mg
  • $ 75.90
  • Sigma-Aldrich
  • Omeprazole for peak identification European Pharmacopoeia (EP) Reference Standard
  • y0001042
  • $ 190.00
  • Sigma-Aldrich
  • Omeprazole
  • 50mg
  • $ 147.00
Total 301 raw suppliers
Chemical Property of Omeprazole Edit
Chemical Property:
  • Appearance/Colour:white crystalline solid 
  • Melting Point:156 °C 
  • Boiling Point:599.991 °C at 760 mmHg 
  • PKA:pKa 4.14/8.9(H2O,t =25,I=0.025) (Uncertain) 
  • Flash Point:316.663 °C 
  • PSA:96.31000 
  • Density:1.371 g/cm3 
  • LogP:3.76540 
  • Storage Temp.:2-8°C 
  • Solubility.:H2O: 0.5 mg/mL 
  • Water Solubility.:Soluble in water (0.5 mg/ml), DMSO (25 mg/ml), and ethanol (4.5 mg/ml). 
  • XLogP3:2.2
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:6
  • Rotatable Bond Count:5
  • Exact Mass:345.11471265
  • Heavy Atom Count:24
  • Complexity:453
Purity/Quality:

99% *data from raw suppliers

Omeprazole *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi,T,F 
  • Statements: 36/37/38-39/23/24/25-23/24/25-11 
  • Safety Statements: 26-36-37/39-45-36/37-16-7 
MSDS Files:

SDS file from LookChem

Useful:
  • Drug Classes:Antiulcer Agents
  • Canonical SMILES:CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC
  • Recent ClinicalTrials:Recurrence Rate Comparison Between Esomeprazole and Lansoprazole in Eradicating Helicobacter Pylori Infection Among Children
  • Recent EU Clinical Trials:'A Phase III Study to Assess the Efficacy and Safety of NEXIUM for Maintenance of Healing of Erosive Esophagitis in Pediatric Patients 1 to 11 Years of Age'
  • Recent NIPH Clinical Trials:V-POINT study
  • Description Omeprazole is a potent gastric antisecretory agent with selective inhibitory effect on the H+,K+-ATPase proton pump. It is highly effective in the treatment of duodenal ulcer and Zollinger-Ellison syndrome, and is reportedly superior to ranitidine in the management of reflux esophagitis.
  • Uses Omeprazole is a proton pump inhibitor used to treat diseases like gastroesophageal reflux disease (GERD), used for gastric and duodenal ulcers, reflux or erosive esophagitis, and Zollinger-Ellison syndrome. It is also effective for gastric and duodenal ulcers that are ineffective with H2 receptor antagonists. Injections of Omeprazole can also be used for: 1 gastrointestinal bleeding, such as peptic and anastomic ulcer bleeding, and the prevention of severe diseases (such as cerebral hemorrhage, severe trauma, etc.) and gastric surgery caused by upper intestinal bleeding; 2 acute gastric mucosal damage complicated by stress or nonsteroidal anti-inflammatory drugs; 3 general anesthesia, post-surgery, or coma patients, to prevent acid reflux and aspiration pneumonia; 4 Combined with amoxicillin and clarithromycin, or with metronidazole and clarithromycin, it can effectively kill Helicobacter pylori (Hp).
  • Therapeutic Function Antiulcer
  • Clinical Use Omeprazole is a proton-pump inhibitor used in the management and treatment of several conditions, including uncomplicated heartburn, peptic ulcer disease, gastrointestinal reflux disease, Zollinger-Ellison syndrome, multiple endocrine adenomas, systemic mastocytosis, erosive esophagitis, gastric ulcers, and helicobacter pylori infection.
  • Drug interactions Potentially hazardous interactions with other drugs Anticoagulants: effect of coumarins possibly enhanced. Antiepileptics: effects of phenytoin possibly enhanced. Antifungals: absorption of itraconazole and ketoconazole reduced; avoid with posaconazole; concentration increased by voriconazole. Antivirals: reduced atazanavir concentration - avoid; AUC of saquinavir increased by 82% (increased risk of toxicity) - avoid; concentration of raltegravir possibly increased - avoid; concentration of rilpivirine reduced - avoid; concentration of omeprazole reduced by tipranavir. Ciclosporin: variable response; mostly increase in ciclosporin level. Cilostazol: increased cilostazol concentration - reduce cilostazol dose. Clopidogrel: avoid due to reduced efficacy of clopidogrel. Cytotoxics: possibly reduced excretion of methotrexate; avoid with erlotinib and vandetanib; possibly reduced dasatinib and lapatinib absorption - avoid with dasatinib; possibly reduced absorption of pazopanib. Tacrolimus: may increase tacrolimus concentration. Ulipristal: reduced contraceptive effect, avoid with high dose ulipristal.
Technology Process of Omeprazole

There total 32 articles about Omeprazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
6-methoxy-1H-benzoimidazole-2-thiol; With sodium hydroxide; In ethanol; water; at 70 - 90 ℃;
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride; With hydrogenchloride; In ethanol; water; at -10 - 30 ℃; for 4h; Reflux;
Guidance literature:
With dihydrogen peroxide; molybdenyl acetylacetonate; In methanol; water; at 0 - 5 ℃; for 3h;
Guidance literature:
4-methoxy-2,3,5-trimethylpyridine; With n-butyllithium; In tetrahydrofuran; at -90 - -80 ℃; for 0.5h;
(-)-menthyl 5-methoxy-2-benzimidazolylsulphinate; In tetrahydrofuran; at -80 - -20 ℃;
With water; In tetrahydrofuran; at -20 ℃;
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