1-(2-chloro-2-phenyl-ethyl)-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid propyl ester

Base Information

• Chemical Name: 1-(2-chloro-2-phenyl-ethyl)-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid propyl ester
• CAS No.: 871038-97-0
• Molecular Formula: C₁₈H₁₈ClN₃O₃
• Molecular Weight: 359.812

Synonyms:1-(2-chloro-2-phenyl-ethyl)-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid propyl ester

Chemical Property of 1-(2-chloro-2-phenyl-ethyl)-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid propyl ester

Chemical Property:

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Technology Process of 1-(2-chloro-2-phenyl-ethyl)-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid propyl ester

There total 2 articles about 1-(2-chloro-2-phenyl-ethyl)-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-(2-chloro-2-phenylethyl)-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid (1044751-58-7) + propan-1-ol (71-23-8) → 1-(2-chloro-2-phenyl-ethyl)-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid propyl ester (871038-97-0)

Guidance literature:

With sulfuric acid; for 18h; Heating;

DOI:10.1021/jm050407k

Reference yield:

4-chloro-1-(2-chloro-2-phenyl-ethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (383911-64-6) → 1-(2-chloro-2-phenyl-ethyl)-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid propyl ester (871038-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / aq. H₂SO₄ / ethanol / 24 h / Heating

2: 75 percent / H₂SO₄ / 18 h / Heating

With sulfuric acid; In ethanol;

DOI:10.1021/jm050407k

Reference yield: 70.0%

1-(2-chloro-2-phenyl-ethyl)-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid propyl ester (871038-97-0) → 4-chloro-1-(2-chloro-2-phenyl-ethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid propyl ester (871038-12-9)

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; In chloroform; for 8h; Heating;

DOI:10.1021/jm050407k

upstream raw materials:

1-(2-chloro-2-phenylethyl)-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

propan-1-ol

4-chloro-1-(2-chloro-2-phenyl-ethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Downstream raw materials:

4-chloro-1-(2-chloro-2-phenyl-ethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid propyl ester

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