(1R,4S,6R)-4-[(tert-butyldimethylsilyl)oxy]-6-methyl-1-[(p-tolylsulfonyl)methyl]-2-cyclohexen-1-ol

Base Information

Chemical Name:(1R,4S,6R)-4-[(tert-butyldimethylsilyl)oxy]-6-methyl-1-[(p-tolylsulfonyl)methyl]-2-cyclohexen-1-ol
CAS No.:473536-56-0
Molecular Formula:C₂₁H₃₄O₄SSi
Molecular Weight:410.65
Hs Code.:

Synonyms:(1R,4S,6R)-4-[(tert-butyldimethylsilyl)oxy]-6-methyl-1-[(p-tolylsulfonyl)methyl]-2-cyclohexen-1-ol

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Chemical Property of (1R,4S,6R)-4-[(tert-butyldimethylsilyl)oxy]-6-methyl-1-[(p-tolylsulfonyl)methyl]-2-cyclohexen-1-ol

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Technology Process of (1R,4S,6R)-4-[(tert-butyldimethylsilyl)oxy]-6-methyl-1-[(p-tolylsulfonyl)methyl]-2-cyclohexen-1-ol

There total 6 articles about (1R,4S,6R)-4-[(tert-butyldimethylsilyl)oxy]-6-methyl-1-[(p-tolylsulfonyl)methyl]-2-cyclohexen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 473536-55-9
(1R,4S,6R)-6-methyl-1-[(p-tolylsulfonyl)methyl]-2-cyclohexen-1,4-diol

: 473536-56-0
(1R,4S,6R)-4-[(tert-butyldimethylsilyl)oxy]-6-methyl-1-[(p-tolylsulfonyl)methyl]-2-cyclohexen-1-ol

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1002/chem.200600809

Reference yield:

: 473536-52-6
(SS)-4-hydroxy-4-[(p-tolylsulfinyl)methyl]-cyclohexa-2,5-dienone

: 473536-56-0
(1R,4S,6R)-4-[(tert-butyldimethylsilyl)oxy]-6-methyl-1-[(p-tolylsulfonyl)methyl]-2-cyclohexen-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / CH₂Cl₂; heptane / 4 h / -78 °C

2: 96 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

3: 99 percent / DIBALH / tetrahydrofuran; hexane / 0.5 h / -78 °C

4: 93 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 °C

With 2,6-dimethylpyridine; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; n-heptane; dichloromethane;
DOI:10.1002/chem.200600809

Reference yield:

: 473536-53-7
[4R,5R,SS]-4-hydroxy-5-methyl-4-[(p-tolylsulfinyl)methyl]-2-cyclohexen-1-one

: 473536-56-0
(1R,4S,6R)-4-[(tert-butyldimethylsilyl)oxy]-6-methyl-1-[(p-tolylsulfonyl)methyl]-2-cyclohexen-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

2: 99 percent / DIBALH / tetrahydrofuran; hexane / 0.5 h / -78 °C

3: 93 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 °C

With 2,6-dimethylpyridine; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/chem.200600809