20S-(dimethylamino)-3β-isobutyrylamino-4β,14α-dimethyl-4α-{[(p-methylbenzenesulfonyl)oxy]methyl}-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

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Chemical Name:20S-(dimethylamino)-3β-isobutyrylamino-4β,14α-dimethyl-4α-{[(p-methylbenzenesulfonyl)oxy]methyl}-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate
CAS No.:1310344-29-6
Molecular Formula:C₄₄H₆₀N₂O₇S
Molecular Weight:761.036
Hs Code.:

20S-(dimethylamino)-3β-isobutyrylamino-4β,14α-dimethyl-4α-{[(p-methylbenzenesulfonyl)oxy]methyl}-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

Synonyms:20S-(dimethylamino)-3β-isobutyrylamino-4β,14α-dimethyl-4α-{[(p-methylbenzenesulfonyl)oxy]methyl}-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

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Chemical Property of 20S-(dimethylamino)-3β-isobutyrylamino-4β,14α-dimethyl-4α-{[(p-methylbenzenesulfonyl)oxy]methyl}-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

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Technology Process of 20S-(dimethylamino)-3β-isobutyrylamino-4β,14α-dimethyl-4α-{[(p-methylbenzenesulfonyl)oxy]methyl}-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

There total 3 articles about 20S-(dimethylamino)-3β-isobutyrylamino-4β,14α-dimethyl-4α-{[(p-methylbenzenesulfonyl)oxy]methyl}-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1310344-14-9
N-[20S-(dimethylamino)-3β-(isobutanamido)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl] benzoate

: 98-59-9
p-toluenesulfonyl chloride

: 1310344-29-6
20S-(dimethylamino)-3β-isobutyrylamino-4β,14α-dimethyl-4α-{[(p-methylbenzenesulfonyl)oxy]methyl}-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

Guidance literature:: With pyridine; toluene-4-sulfonic acid; at 20 - 90 ℃; for 3.5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.02.073

Reference yield:

: N-[(3β,4α,9β,16α,20S)-20-(dimethylamino)-16-hydroxy-4-(hydroxymethyl)-4,14-dimethyl-11-oxo-9,19-cyclopregnan-3-yl]-2-methylpropanamide

: 1310344-29-6
20S-(dimethylamino)-3β-isobutyrylamino-4β,14α-dimethyl-4α-{[(p-methylbenzenesulfonyl)oxy]methyl}-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 13 h / 0 - 20 °C / Inert atmosphere

2: pyridine; toluene-4-sulfonic acid / 3.5 h / 20 - 90 °C / Inert atmosphere

With pyridine; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2011.02.073

Reference yield:

: 93-97-0
benzoic acid anhydride

: 1310344-29-6
20S-(dimethylamino)-3β-isobutyrylamino-4β,14α-dimethyl-4α-{[(p-methylbenzenesulfonyl)oxy]methyl}-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 13 h / 0 - 20 °C / Inert atmosphere

2: pyridine; toluene-4-sulfonic acid / 3.5 h / 20 - 90 °C / Inert atmosphere

With pyridine; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2011.02.073