(6R,7R)-benzhydryl-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Base Information

Chemical Name:(6R,7R)-benzhydryl-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.:67366-01-2
Molecular Formula:C₃₁H₂₈N₆O₄S₂
Molecular Weight:612.733
Hs Code.:

Synonyms:(6R,7R)-benzhydryl-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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Chemical Property of (6R,7R)-benzhydryl-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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Technology Process of (6R,7R)-benzhydryl-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

There total 5 articles about (6R,7R)-benzhydryl-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.2%

: 68474-81-7
C₃₁H₂₈N₆O₅S₂

: 67366-01-2
(6R,7R)-benzhydryl-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: With phosphorus trichloride; In dichloromethane; for 3h; Reflux;
DOI:10.1007/s13738-016-0815-0

Reference yield:

: 957-68-6
7-Aminocephalosporanic acid

: 67366-01-2
(6R,7R)-benzhydryl-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: boron trifluoride diethyl etherate / acetonitrile / 2.5 h / 50 °C

2: sodium hydrogencarbonate / water; acetone / 3.67 h / 0 - 20 °C

3: dicyclohexyl-carbodiimide; dmap / dichloromethane / -20 °C

4: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 °C

5: phosphorus trichloride / dichloromethane / 3 h / Reflux

With dmap; boron trifluoride diethyl etherate; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; phosphorus trichloride; In dichloromethane; chloroform; water; acetone; acetonitrile;
DOI:10.1007/s13738-016-0815-0

Reference yield:

: 47653-82-7
(6R,7R)-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-aza-bicyclo [4.2.0]oct-2-ene-2-carboxylic acid

: 67366-01-2
(6R,7R)-benzhydryl-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / -20 °C

2: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 °C

3: phosphorus trichloride / dichloromethane / 3 h / Reflux

With dmap; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; phosphorus trichloride; In dichloromethane; chloroform;
DOI:10.1007/s13738-016-0815-0