47653-82-7Relevant articles and documents
A novel synthetic route to 7-MAC from 7-ACA
Xiong, Fei,Li, Gen,Song, Bo,Chen, Fen-Er,Zeng, Zhao-Sen
, p. 1019 - 1025 (2016)
An efficient and practical seven-step procedure is described for the synthesis of (6R,7S)-benzhydryl-7-amino-7-methoxy-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo [4.2.0]oct-2-ene-2-carboxylate (7-MAC, 3) with overall yield of 49?%. This synthesis features a convenient and highly selective method for the introduction of 7α-methoxy group to cephalosporin nucleus in 10 using MeOLi/t-BuOCl in THF.
Deprotection of carboxylic esters of β-lactam homologues. Cleavage of p-methoxybenzyl, diphenylmethyl, and tert-butyl esters effected by a phenolic matrix
Torii,Tanaka,Taniguchi,Kameyama,Sasaoka,Shiroi,Kikuchi,Kawahara,Shimabayashi,Nagao
, p. 3633 - 3637 (2007/10/02)
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