1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

Base Information

Chemical Name:1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole
CAS No.:1359029-99-4
Molecular Formula:C₁₉H₂₄BF₃N₂O₂
Molecular Weight:380.218
Hs Code.:

Synonyms:1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

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Chemical Property of 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

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Technology Process of 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

There total 3 articles about 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61676-62-8
2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1356997-87-9
4-iodo-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

: 1359029-99-4
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

Guidance literature:: 4-iodo-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole; With isopropylmagnesium chloride; In tetrahydrofuran; for 2h; Cooling with ice; Inert atmosphere;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at 20 ℃; for 4h; Cooling with ice;

Reference yield:

: 1356997-45-9
1-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}-1H-pyrazole

: 1359029-99-4
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2.1: N-iodo-succinimide; trifluoroacetic acid / 1 h / 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere

3.2: 4 h / 20 °C / Cooling with ice

With N-iodo-succinimide; palladium 10% on activated carbon; hydrogen; isopropylmagnesium chloride; trifluoroacetic acid; In tetrahydrofuran; methanol;

Reference yield:

: 1356997-44-8
1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

: 1359029-99-4
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-iodo-succinimide; trifluoroacetic acid / 1 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere

2.2: 4 h / 20 °C / Cooling with ice

With N-iodo-succinimide; isopropylmagnesium chloride; trifluoroacetic acid; In tetrahydrofuran;