4-(1H-imidazol-4-yl)-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

Base Information

Chemical Name:4-(1H-imidazol-4-yl)-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole
CAS No.:1359029-98-3
Molecular Formula:C₁₆H₁₅F₃N₄
Molecular Weight:320.317
Hs Code.:

Synonyms:4-(1H-imidazol-4-yl)-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

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Chemical Property of 4-(1H-imidazol-4-yl)-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

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Technology Process of 4-(1H-imidazol-4-yl)-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

There total 4 articles about 4-(1H-imidazol-4-yl)-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1359029-99-4
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

: 163854-63-5
4-iodo-1-[(4-methylphenyl)sulfonyl]-1H-imidazole

: 1359029-98-3
4-(1H-imidazol-4-yl)-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1356997-45-9
1-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}-1H-pyrazole

: 1359029-98-3
4-(1H-imidazol-4-yl)-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2.1: N-iodo-succinimide; trifluoroacetic acid / 1 h / 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere

3.2: 4 h / 20 °C / Cooling with ice

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene; water / 16 h / 100 °C / Inert atmosphere

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; isopropylmagnesium chloride; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; water; toluene;

Reference yield:

: 1356997-44-8
1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

: 1359029-98-3
4-(1H-imidazol-4-yl)-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-iodo-succinimide; trifluoroacetic acid / 1 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere

2.2: 4 h / 20 °C / Cooling with ice

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene; water / 16 h / 100 °C / Inert atmosphere

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; isopropylmagnesium chloride; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; ethanol; water; toluene;