(2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanol

Base Information

• Chemical Name: (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanol
• CAS No.: 934980-08-2
• Molecular Formula: C₂₇H₃₅NO₃
• Molecular Weight: 421.58
• Mol file: 934980-08-2.mol

Synonyms:(2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanol

Chemical Property of (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanol

There total 5 articles about (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate (852468-46-3) → (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanol (934980-08-2)

Guidance literature:

With lithium borohydride; In diethyl ether; at 20 ℃; for 2h;

DOI:10.1021/jo0625608

Reference yield:

ethyl (4S,2E)-4-(4-methoxybenzylamino)-2-methyl-5-phenylpent-2-enoate (852468-44-1) → (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanol (934980-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / hydrogen / Pd/C / methanol

2: 90 percent / LiBH₄ / diethyl ether / 2 h / 20 °C

With lithium borohydride; hydrogen; palladium on activated charcoal; In methanol; diethyl ether;

DOI:10.1021/jo0625608

Reference yield:

ethyl (4S,2E)-4-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]-2-methyl-5-phenylpent-2-enoate (852468-42-9) → (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanol (934980-08-2)

Guidance literature:

Multi-step reaction with 4 steps

1: TFA / CH₂Cl₂ / 1 h / 0 °C

2: 88 percent / hydrogen / Pd/C / methanol

3: 90 percent / LiBH₄ / diethyl ether / 2 h / 20 °C

With lithium borohydride; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;

DOI:10.1021/jo0625608

upstream raw materials:

ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate

ethyl (4S,2E)-4-(4-methoxybenzylamino)-2-methyl-5-phenylpent-2-enoate

ethyl (4S,2E)-4-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]-2-methyl-5-phenylpent-2-enoate

(S)-2-[N-tert-butoxycarbonyl-N-(4′-Methoxybenzyl)amino]-3-phenylpropionaldehyde