ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate

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Chemical Name:ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate
CAS No.:852468-46-3
Molecular Formula:C₂₉H₃₇NO₄
Molecular Weight:463.617
Hs Code.:

Synonyms:ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate

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Chemical Property of ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate

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Technology Process of ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate

There total 11 articles about ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]deca-6,8-dien-4-yl]propanoate

: 852468-46-3
ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jo0625608

Reference yield:

: 169905-23-1
(S)-2-[N-tert-butoxycarbonyl-N-(4′-Methoxybenzyl)amino]-3-phenylpropionaldehyde

: 852468-46-3
ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 - 0 °C

1.2: tetrahydrofuran; hexane / 3 h / -78 °C

2.1: TFA / CH₂Cl₂ / 1 h / 0 °C

3.1: 88 percent / hydrogen / Pd/C / methanol

With n-butyllithium; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; 1.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo0625608

Reference yield:

: 852468-42-9
ethyl (4S,2E)-4-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]-2-methyl-5-phenylpent-2-enoate

: 852468-46-3
ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: TFA / CH₂Cl₂ / 1 h / 0 °C

2: 88 percent / hydrogen / Pd/C / methanol

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo0625608