7-benzyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 7-benzyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one
• CAS No.: 119260-93-4
• Molecular Formula: C₁₆H₁₅N₃OS
• Molecular Weight: 297.381
• Mol file: 119260-93-4.mol

Synonyms:7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one

Chemical Property of 7-benzyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-benzyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one

There total 3 articles about 7-benzyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tinoridine (24237-54-5) + formamide (77287-34-4,77287-35-5,60100-09-6) → 7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one (119260-93-4)

Guidance literature:

for 1.5h; Reflux;

DOI:10.3390/molecules15063932

Reference yield:

formamidine acetic acid (3473-63-0) + C14H16N2S → 7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one (119260-93-4)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 6h;

DOI:10.1016/j.ejmech.2020.112076

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one (119260-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur; triethylamine / ethanol / 12 h / 80 °C

2: N,N-dimethyl-formamide / 6 h / 100 °C

With sulfur; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2020.112076

upstream raw materials:

tinoridine

formamide

1-phenylmethyl-4-piperidone

formamidine acetic acid

Downstream raw materials:

7-Benzyl-4-chloro-5,6,7,8-tetrahydro-pyrido[4',3':4,5]thieno[2,3-d]pyrimidine

2-(7-Benzyl-5,6,7,8-tetrahydro-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)-ethanol

9-Benzyl-2,3,8,9,10,11-hexahydro-pyrido<4',3':4,5>thieno<3,2-e>imidazo<1,2-c>pyrimidin

10-Benzyl-3,4,9,10,11,12-hexahydro-2H-pyrido<4',3':4,5>thieno<3,2-e>pyrimido<1,2-c>pyrimidin