1-benzyl-4-(tert-butyldimethylsilyl)-5-(trifluoromethyl)-1H-[1,2,3]triazole

Base Information

• Chemical Name: 1-benzyl-4-(tert-butyldimethylsilyl)-5-(trifluoromethyl)-1H-[1,2,3]triazole
• CAS No.: 1295573-05-5
• Molecular Formula: C₁₆H₂₂F₃N₃Si
• Molecular Weight: 341.451
• Mol file: 1295573-05-5.mol

Synonyms:1-benzyl-4-(tert-butyldimethylsilyl)-5-(trifluoromethyl)-1H-[1,2,3]triazole

Chemical Property of 1-benzyl-4-(tert-butyldimethylsilyl)-5-(trifluoromethyl)-1H-[1,2,3]triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-(tert-butyldimethylsilyl)-5-(trifluoromethyl)-1H-[1,2,3]triazole

There total 2 articles about 1-benzyl-4-(tert-butyldimethylsilyl)-5-(trifluoromethyl)-1H-[1,2,3]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 1-benzyl-4-(tert-butyldimethylsilyl)-5-(trifluoromethyl)-1H-[1,2,3]triazole (1295573-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: toluene / 30 h / 85 °C / Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexane; toluene; 2.1: 1,3-dipolar cycloaddition;

DOI:10.1016/j.jfluchem.2010.12.012

Reference yield:

3,3,3-trifluoro-1-tert-butyldimethylsilylpropyne (1295573-04-4) + benzyl azide (622-79-7) → 1-benzyl-4-(tert-butyldimethylsilyl)-5-(trifluoromethyl)-1H-[1,2,3]triazole (1295573-05-5)

Guidance literature:

In toluene; at 85 ℃; for 30h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.jfluchem.2010.12.012

Reference yield: 88.0%

1-benzyl-4-(tert-butyldimethylsilyl)-5-(trifluoromethyl)-1H-[1,2,3]triazole (1295573-05-5) → 1-benzyl-5-(trifluoromethyl)-1H-[1,2,3]triazole (1295573-15-7)

Guidance literature:

With hydrogen fluoride; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1016/j.jfluchem.2010.12.012

upstream raw materials:

3,3,3-trifluoro-1-tert-butyldimethylsilylpropyne

benzyl azide

tert-butyldimethylsilyl chloride

Downstream raw materials:

1-benzyl-5-(trifluoromethyl)-1H-[1,2,3]triazole