(S)-6-Benzyloxy-2-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-3-methyl-hexanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Base Information

• Chemical Name: (S)-6-Benzyloxy-2-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-3-methyl-hexanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester
• CAS No.: 141062-33-1
• Molecular Formula: C₃₅H₅₂N₂O₅
• Molecular Weight: 580.808
• Mol file: 141062-33-1.mol

Synonyms:(S)-6-Benzyloxy-2-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-3-methyl-hexanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Chemical Property of (S)-6-Benzyloxy-2-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-3-methyl-hexanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-Benzyloxy-2-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-3-methyl-hexanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

There total 5 articles about (S)-6-Benzyloxy-2-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-3-methyl-hexanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-amino-2-(methoxymethyl)pyrrolidine (59983-39-0,187035-29-6) → (S)-6-Benzyloxy-2-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-3-methyl-hexanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester (141062-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent

2: 1) tBuOK, nBuLi / 1) THF, hexane, -90 - -78 deg C, 2 h, 2a) -100 deg C, 2 h, b) 0 deg C to r. t., 12 h

With n-butyllithium; potassium tert-butylate;

Reference yield:

2,6-Di-t-butyl-4-methoxyphenol (489-01-0) → (S)-6-Benzyloxy-2-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-3-methyl-hexanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester (141062-33-1)

Guidance literature:

Multi-step reaction with 4 steps

1: nBuLi / tetrahydrofuran / 0 °C

2: 98 percent / diethyl ether / -78 °C

3: 96 percent

4: 1) tBuOK, nBuLi / 1) THF, hexane, -90 - -78 deg C, 2 h, 2a) -100 deg C, 2 h, b) 0 deg C to r. t., 12 h

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; diethyl ether;

Reference yield:

2,6-di-tert-butyl-4-methoxyphenyl ethyl oxalate (609798-33-6) → (S)-6-Benzyloxy-2-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-3-methyl-hexanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester (141062-33-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / diethyl ether / -78 °C

2: 96 percent

3: 1) tBuOK, nBuLi / 1) THF, hexane, -90 - -78 deg C, 2 h, 2a) -100 deg C, 2 h, b) 0 deg C to r. t., 12 h

With n-butyllithium; potassium tert-butylate; In diethyl ether;

upstream raw materials:

3-benzyloxypropyl iodide

2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

2,6-Di-t-butyl-4-methoxyphenol

(S)-1-amino-2-(methoxymethyl)pyrrolidine