ethyl 2-(4-carbethoxyphenyl)-4-oxo-4,5-dihydro-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-9-acetate

Base Information

Chemical Name:ethyl 2-(4-carbethoxyphenyl)-4-oxo-4,5-dihydro-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-9-acetate
CAS No.:193814-07-2
Molecular Formula:C₂₆H₂₃N₃O₅
Molecular Weight:457.486
Hs Code.:

Synonyms:ethyl 2-(4-carbethoxyphenyl)-4-oxo-4,5-dihydro-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-9-acetate

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Chemical Property of ethyl 2-(4-carbethoxyphenyl)-4-oxo-4,5-dihydro-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-9-acetate

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Technology Process of ethyl 2-(4-carbethoxyphenyl)-4-oxo-4,5-dihydro-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-9-acetate

There total 8 articles about ethyl 2-(4-carbethoxyphenyl)-4-oxo-4,5-dihydro-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-9-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60-29-7,927820-24-4
diethyl ether

: 193814-08-3
ethyl 1-(4-carbethoxymethyl-1-oxoindan-2-yl)-4-(4-carbethoxyphenyl)imidazole-2-carboxylate

: 193814-07-2
ethyl 2-(4-carbethoxyphenyl)-4-oxo-4,5-dihydro-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-9-acetate

Guidance literature:: With ammonium acetate; In acetic acid;

Reference yield:

: 18698-97-0
ortho-bromophenylacetic acid

: 193814-07-2
ethyl 2-(4-carbethoxyphenyl)-4-oxo-4,5-dihydro-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-9-acetate

Guidance literature:: Multi-step reaction with 7 steps

1: Pd(OAc)2; tri-o-tolylphosphine

2: H₂ / Pd/C

3: conc. H₂SO₄

4: 57 percent / (COCl)2

5: Br₂ / CH₂Cl₂ / 20 °C

6: K₂CO₃ / acetone / Heating

7: AcONH₄; AcOH / Heating

With palladium diacetate; oxalyl dichloride; sulfuric acid; ammonium acetate; hydrogen; bromine; potassium carbonate; acetic acid; tris-(o-tolyl)phosphine; palladium on activated charcoal; In dichloromethane; acetone; 1: Heck reaction / 3: Friedel-Craft cyclization;
DOI:10.1016/S0960-894X(00)00592-8

Reference yield:

: 183734-98-7
3-(2-carboxymethylphenyl)acrylic acid

: 193814-07-2
ethyl 2-(4-carbethoxyphenyl)-4-oxo-4,5-dihydro-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-9-acetate

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C

2: conc. H₂SO₄

3: 57 percent / (COCl)2

4: Br₂ / CH₂Cl₂ / 20 °C

5: K₂CO₃ / acetone / Heating

6: AcONH₄; AcOH / Heating

With oxalyl dichloride; sulfuric acid; ammonium acetate; hydrogen; bromine; potassium carbonate; acetic acid; palladium on activated charcoal; In dichloromethane; acetone; 2: Friedel-Craft cyclization;
DOI:10.1016/S0960-894X(00)00592-8