(2R,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

Base Information

Chemical Name:(2R,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol
CAS No.:81470-83-9
Molecular Formula:C₂₆H₄₀O₄Si
Molecular Weight:444.687
Hs Code.:

Synonyms:(2R,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

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Chemical Property of (2R,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

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Technology Process of (2R,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

There total 19 articles about (2R,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 81470-82-8
(2R,3R,4S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-4-((4S,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-pentan-3-ol

: 81470-83-9
(2R,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

Guidance literature:: With acetic acid; In water; at 40 ℃; for 0.166667h;
DOI:10.1016/S0040-4020(01)93261-2

Reference yield:

: 81470-77-1,98102-72-8,100760-30-3,115181-74-3,133006-91-4,135211-99-3,138124-14-8,145514-09-6
(2S,3R,4R)-1-(benzyloxy)-3,5-(isopropylidenedioxy)-2,4-dimethylpentane

: 81470-83-9
(2R,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / liquid ammonia, Li / tetrahydrofuran / 0.33 h / Heating

2: oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 0.25 h / -78 °C

3: 86 percent / chromic chloride, LAH / tetrahydrofuran / 0.5 h

5: 100 percent / AcOH / H₂O / 0.17 h / 40 °C

With lithium aluminium tetrahydride; oxalyl dichloride; ammonia; chromium(III) chloride; lithium; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4020(01)93261-2

Reference yield:

: 81470-73-7
ethyl (4R,2E)-5-(benzyloxy)-4-methylpent-2-enoate

: 81470-83-9
(2R,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / DIBAL / CH₂Cl₂; hexane / 0.67 h

2: titanium tetraisopropoxide, t-butyl hydroperoxide / D(-)-diethyl tartrate / CH₂Cl₂ / 0.67 h / -23 °C

3: 89 percent / copper (I) iodide / diethyl ether / -40 deg C, 5 h. then -23 deg C, 30 min.

4: 92 percent / camphorsulfonic acid / acetone / 0.5 h / 25 °C

5: 96 percent / liquid ammonia, Li / tetrahydrofuran / 0.33 h / Heating

6: oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 0.25 h / -78 °C

7: 86 percent / chromic chloride, LAH / tetrahydrofuran / 0.5 h

9: 100 percent / AcOH / H₂O / 0.17 h / 40 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; lithium aluminium tetrahydride; oxalyl dichloride; camphor-10-sulfonic acid; ammonia; chromium(III) chloride; lithium; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; diethyl (2S,3S)-tartrate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(01)93261-2