2,2-Dimethyl-propionic acid (2R,3R,4R,5R,6R)-7-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-2,4,6-trimethyl-heptyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (2R,3R,4R,5R,6R)-7-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-2,4,6-trimethyl-heptyl ester
CAS No.:81470-84-0
Molecular Formula:C₃₁H₄₈O₅Si
Molecular Weight:528.805
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (2R,3R,4R,5R,6R)-7-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-2,4,6-trimethyl-heptyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (2R,3R,4R,5R,6R)-7-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-2,4,6-trimethyl-heptyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (2R,3R,4R,5R,6R)-7-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-2,4,6-trimethyl-heptyl ester

There total 15 articles about 2,2-Dimethyl-propionic acid (2R,3R,4R,5R,6R)-7-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-2,4,6-trimethyl-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 3282-30-2
pivaloyl chloride

: 81470-83-9
(2R,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

: 81470-84-0
2,2-Dimethyl-propionic acid (2R,3R,4R,5R,6R)-7-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-2,4,6-trimethyl-heptyl ester

Guidance literature:: With pyridine; In dichloromethane; 0 deg C, 1.5 h. then room temp., 2 h.;
DOI:10.1016/S0040-4020(01)93261-2

Reference yield:

: 81470-77-1,98102-72-8,100760-30-3,115181-74-3,133006-91-4,135211-99-3,138124-14-8,145514-09-6
(2S,3R,4R)-1-(benzyloxy)-3,5-(isopropylidenedioxy)-2,4-dimethylpentane

: 81470-84-0
2,2-Dimethyl-propionic acid (2R,3R,4R,5R,6R)-7-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-2,4,6-trimethyl-heptyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / liquid ammonia, Li / tetrahydrofuran / 0.33 h / Heating

2: oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 0.25 h / -78 °C

3: 86 percent / chromic chloride, LAH / tetrahydrofuran / 0.5 h

5: 100 percent / AcOH / H₂O / 0.17 h / 40 °C

6: 92 percent / pyridine / CH₂Cl₂ / 0 deg C, 1.5 h. then room temp., 2 h.

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; ammonia; chromium(III) chloride; lithium; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4020(01)93261-2

Reference yield:

: 108393-30-2
(2R,3R,4R)-5-(benzyloxy)-2,4-dimethyl-1,3-pentanediol

: 81470-84-0
2,2-Dimethyl-propionic acid (2R,3R,4R,5R,6R)-7-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-2,4,6-trimethyl-heptyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / camphorsulfonic acid / acetone / 0.5 h / 25 °C

2: 96 percent / liquid ammonia, Li / tetrahydrofuran / 0.33 h / Heating

3: oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 0.25 h / -78 °C

4: 86 percent / chromic chloride, LAH / tetrahydrofuran / 0.5 h

6: 100 percent / AcOH / H₂O / 0.17 h / 40 °C

7: 92 percent / pyridine / CH₂Cl₂ / 0 deg C, 1.5 h. then room temp., 2 h.

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; camphor-10-sulfonic acid; ammonia; chromium(III) chloride; lithium; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(01)93261-2