N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-2-ethylbutanamide

Base Information

Chemical Name:N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-2-ethylbutanamide
CAS No.:1595286-06-8
Molecular Formula:C₁₈H₁₈ClFN₄OS
Molecular Weight:392.885
Hs Code.:

Synonyms:N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-2-ethylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-2-ethylbutanamide

Chemical Property:

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Technology Process of N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-2-ethylbutanamide

There total 6 articles about N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-2-ethylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 2736-40-5
chlorure d'acide ethyl-2 butyrique

: 1595286-21-7
N⁴-(3-chloro-4-fluorophenyl)thieno[2,3-d]pyrimidine-4,6-diamine

: 1595286-06-8
N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-2-ethylbutanamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2014.01.035

Reference yield:

: 56844-41-8
6-nitrothieno[2,3-d]pyrimidin-4-ol

: 1595286-06-8
N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-2-ethylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate; triethylamine / acetonitrile / 3 h / 70 °C

2: isopropyl alcohol / 2 h / 20 - 80 °C

3: iron; ammonium chloride / ethanol / 1 h / 45 °C

4: triethylamine / tetrahydrofuran / 0 - 20 °C

With iron; ammonium chloride; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmc.2014.01.035

Reference yield:

: 4651-81-4
Methyl 2-aminothiophene-3-carboxylate

: 1595286-06-8
N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-2-ethylbutanamide

Guidance literature:: Multi-step reaction with 6 steps

1: Microwave irradiation

2: sulfuric acid; nitric acid / 2 h / 90 °C

3: trichlorophosphate; triethylamine / acetonitrile / 3 h / 70 °C

4: isopropyl alcohol / 2 h / 20 - 80 °C

5: iron; ammonium chloride / ethanol / 1 h / 45 °C

6: triethylamine / tetrahydrofuran / 0 - 20 °C

With sulfuric acid; nitric acid; iron; ammonium chloride; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmc.2014.01.035