56844-41-8

Basic information

• Product Name: AKOS 90188
• Synonyms: AKOS 90188;6-Nitrothieno[2,3-D]Pyrimidin-4(3H)-One
• CAS NO: 56844-41-8
• Molecular Formula: C₆H₃N₃O₃S
• Molecular Weight: 197.17132
• Mol File: 56844-41-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AKOS 90188(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS 90188(56844-41-8)
• EPA Substance Registry System: AKOS 90188(56844-41-8)

Safety Data

• Hazardous Substances Data: 56844-41-8(Hazardous Substances Data)

Upstream product

• 14080-50-3 thieno[2,3-d]pyrimidin-4(3H)one 
• 55654-21-2 methyl 2-formylaminothiophene-3-carboxylate 
• 14080-50-3 4-hydroxythieno[2,3-d]pyrimidine 
• 4651-81-4 Methyl 2-aminothiophene-3-carboxylate 
• 43028-71-3 2-formylaminothiophene-3-carboxamide 
• 4651-82-5 2-amino-3-cyanothiophene 
• 77287-34-4 formamide 
• 42783-04-0 2-amino-3-ethoxycarbonyl-5-nitrothiophene 

Downstream Products

• 1595286-20-6 N-(3-chloro-4-fluorophenyl)-6-nitrothieno[2,3-d]pyrimidin-4-amine 
• 1595286-21-7 N⁴-(3-chloro-4-fluorophenyl)thieno[2,3-d]pyrimidine-4,6-diamine 

Relevant articles and documents

6-Cinnamoyl-4-arylaminothienopyrimidines as highly potent cytotoxic agents: Design, synthesis and structure-activity relationship studies

In this paper, we described the synthesis and cytotoxic activities of two new series of thieno[2,3-d]pyrimidine and thieno[3,2-d] pyrimidine derivatives. Most of the synthesized compounds had significant antiproliferative activities against PC3, MDA-MB-23

Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors

A novel series of 6-alkenylamides of 4-anilinothieno[2,3-d]pyrimidine derivatives was designed, synthesized and evaluated as irreversible inhibitors of the epidermal growth factor receptor (EGFR). Most of the compounds exhibited good potency against EGFR wild type (EGFR wt) and EGFR T790M/L858R. Among these, the half-maximal inhibitory concentration (IC50) values of 17 compounds against EGFR wt were less than 0.020 μM, and those of 12 compounds were less than 0.010 μM. The IC50 values of 10 compounds against EGFR T790M/L858R were less than 0.005 μM. Compounds 8l, 9n, 9o, 9q and 9v almost completely blocked the phosphorylation of EGFR in the A431 cell line at 1 μM. Compounds 8l, 9n, 9o, 9q and 9v blocked the autophosphorylation of EGFR in NCI-H1975 cells at high concentration (1 μM), and compound 8l was confirmed to be an irreversible inhibitor through the dilution method.

2-Amino-5-nitrothiophen-3-carbonsaeureester aus 1,1-Dimethyl-amino-2-nitroethylen, Cyanessigsaeureester und Schwefel

-