Technology Process of N-[(4-chlorophenyl)-methyl]-2-isopropyl-6-methoxy-4-morpholin-4-yl-benzamide
There total 8 articles about N-[(4-chlorophenyl)-methyl]-2-isopropyl-6-methoxy-4-morpholin-4-yl-benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide;
In
tetrahydrofuran; water; benzene;
at 23 - 90 ℃;
for 0.75h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: dimethyl sulfoxide / 2 h / 23 - 100 °C
2: caesium carbonate / dichloromethane; acetonitrile / 2 h / 23 °C
3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / N,N-dimethyl-formamide / 16.33 h / 120 °C / Inert atmosphere
4: palladium 10% on activated carbon; hydrogen / methanol / 16.33 h / 2585.81 Torr / Inert atmosphere
5: tert.-butylnitrite / dimethyl sulfoxide / 1 h / 50 °C
6: sulfuric acid / 3 h / 100 °C
7: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / benzene; tetrahydrofuran; water / 0.75 h / 23 - 90 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tert.-butylnitrite; sulfuric acid; palladium 10% on activated carbon; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / N,N-dimethyl-formamide / 16.33 h / 120 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / methanol / 16.33 h / 2585.81 Torr / Inert atmosphere
3: tert.-butylnitrite / dimethyl sulfoxide / 1 h / 50 °C
4: sulfuric acid / 3 h / 100 °C
5: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / benzene; tetrahydrofuran; water / 0.75 h / 23 - 90 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tert.-butylnitrite; sulfuric acid; palladium 10% on activated carbon; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
