4-(N,N-Benzylmethylamino)-6-(N-isopropylamino)-2-methylthio-5-nitropyrimidine

Base Information

• Chemical Name: 4-(N,N-Benzylmethylamino)-6-(N-isopropylamino)-2-methylthio-5-nitropyrimidine
• CAS No.: 618863-11-9
• Molecular Formula: C₁₆H₂₁N₅O₂S
• Molecular Weight: 347.441

Synonyms:4-(N,N-Benzylmethylamino)-6-(N-isopropylamino)-2-methylthio-5-nitropyrimidine

Chemical Property of 4-(N,N-Benzylmethylamino)-6-(N-isopropylamino)-2-methylthio-5-nitropyrimidine

Chemical Property:

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Technology Process of 4-(N,N-Benzylmethylamino)-6-(N-isopropylamino)-2-methylthio-5-nitropyrimidine

There total 1 articles about 4-(N,N-Benzylmethylamino)-6-(N-isopropylamino)-2-methylthio-5-nitropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

isopropylamine (75-31-0) + benzyl-methyl-amine (103-67-3) + 4,6-dichloro-2-(methylthio)-5-nitropyrimidine (1979-96-0) → 4-(N,N-Benzylmethylamino)-6-(N-isopropylamino)-2-methylthio-5-nitropyrimidine (618863-11-9)

Guidance literature:

benzyl-methyl-amine; 4,6-dichloro-2-(methylthio)-5-nitropyrimidine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.333333h;

isopropylamine; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2003.09.112

Reference yield: 88.0%

piperidine (110-89-4) + 4-(N,N-Benzylmethylamino)-6-(N-isopropylamino)-2-methylthio-5-nitropyrimidine (618863-11-9) → 4-(N,N-Benzylmethylamino)-6-(N-isopropylamino)-5-nitro-2-piperidinylpyrimidine (618863-12-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.tetlet.2003.09.112

Reference yield:

4-ethoxycarbonylpiperazine (120-43-4) + 4-(N,N-Benzylmethylamino)-6-(N-isopropylamino)-2-methylthio-5-nitropyrimidine (618863-11-9) → 4-[4-(benzyl-methyl-amino)-6-isopropylamino-5-nitro-pyrimidin-2-yl]-piperazine-1-carboxylic acid ethyl ester

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.tetlet.2003.09.112

upstream raw materials:

isopropylamine

benzyl-methyl-amine

4,6-dichloro-2-(methylthio)-5-nitropyrimidine

Downstream raw materials:

4-(N,N-Benzylmethylamino)-6-(N-isopropylamino)-5-nitro-2-piperidinylpyrimidine

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