2-methyl-4-phenoxy-5,6,7,8-tetrahydro-quinolin-8-ol

Base Information

Chemical Name:2-methyl-4-phenoxy-5,6,7,8-tetrahydro-quinolin-8-ol
CAS No.:1354293-72-3
Molecular Formula:C₁₆H₁₇NO₂
Molecular Weight:255.316
Hs Code.:

Synonyms:2-methyl-4-phenoxy-5,6,7,8-tetrahydro-quinolin-8-ol

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Chemical Property of 2-methyl-4-phenoxy-5,6,7,8-tetrahydro-quinolin-8-ol

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Technology Process of 2-methyl-4-phenoxy-5,6,7,8-tetrahydro-quinolin-8-ol

There total 5 articles about 2-methyl-4-phenoxy-5,6,7,8-tetrahydro-quinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1354293-79-0
4-chloro-2-methyl-5,6,7,8-tetrahydro-quinolin-8-ol

: 108-95-2,27073-41-2
phenol

: 1354293-72-3
2-methyl-4-phenoxy-5,6,7,8-tetrahydro-quinolin-8-ol

Guidance literature:: phenol; With 1-methyl-pyrrolidin-2-one; sodium hexamethyldisilazane; at 20 ℃; for 0.666667h;

4-chloro-2-methyl-5,6,7,8-tetrahydro-quinolin-8-ol; at 60 - 175 ℃; for 20.5h;

Reference yield:

: 607-67-0
4-hydroxy-2-methylquinoline

: 1354293-72-3
2-methyl-4-phenoxy-5,6,7,8-tetrahydro-quinolin-8-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / Raney nickel / ethanol / 22 h / 75 °C / 75007.5 Torr / Inert atmosphere

2.1: trichlorophosphate / 3.5 h / 100 °C / Inert atmosphere

2.2: pH 12 / Cooling with ice

3.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 5 h / 0 - 20 °C

3.2: pH 14

4.1: trifluoroacetic anhydride / dichloromethane / 5 h / 0 - 20 °C

4.2: 4.33 h / 20 °C / Cooling with ice

5.1: sodium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 0.67 h / 20 °C

5.2: 20.5 h / 60 - 175 °C

With hydrogen; sodium hexamethyldisilazane; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; trichlorophosphate; Raney nickel; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; chloroform;

Reference yield:

: 18005-13-5
4-chloro-2-methyl-5,6,7,8-tetrahydroquinoline

: 1354293-72-3
2-methyl-4-phenoxy-5,6,7,8-tetrahydro-quinolin-8-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 5 h / 0 - 20 °C

1.2: pH 14

2.1: trifluoroacetic anhydride / dichloromethane / 5 h / 0 - 20 °C

2.2: 4.33 h / 20 °C / Cooling with ice

3.1: sodium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 0.67 h / 20 °C

3.2: 20.5 h / 60 - 175 °C

With sodium hexamethyldisilazane; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In 1-methyl-pyrrolidin-2-one; dichloromethane; chloroform;