3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester

Base Information

Chemical Name:3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester
CAS No.:403508-26-9
Molecular Formula:C₃₁H₃₉IO₅
Molecular Weight:618.552
Hs Code.:

3-(3,6-di-<i>tert</i>-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester

Synonyms:3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester

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Chemical Property of 3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester

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Technology Process of 3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester

There total 1 articles about 3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 15250-46-1
ethyl (4-iodophenyl)acetate

: 274911-45-4
3,6-di-tert-butyl-2,7-dimethoxynaphthalene-1-carbaldehyde

: 403508-26-9
3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester

Guidance literature:: With zinc(II) chloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(01)01564-7

Reference yield: 76.0%

: 403508-26-9
3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester

: 3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-2-(4-iodo-phenyl)-propionic acid

Guidance literature:: 3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester; With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃;

With potassium hydroxide; In ethanol; water; at 100 ℃;
DOI:10.1016/S0040-4039(01)01564-7

Reference yield:

: 403508-26-9
3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester

: C₃₃H₂₉O₂S₄

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃SiH; CF₃COOH / CH₂Cl₂ / 20 °C

1.2: 76 percent / KOH / ethanol; H₂O / 100 °C

2.1: (COCl)2 / 65 °C

2.2: 77 percent / AlCl₃ / CH₂Cl₂ / -78 °C

3.1: 63 percent / Pd(PPh₃)4 / toluene / 120 °C

4.1: LiAlH₄ / tetrahydrofuran / 20 °C

4.2: LiI / hexamethylphosphoric acid triamide / 170 °C

4.3: 53 percent / aq. phosphate buffer / 20 °C / pH 7.0

5.1: 100 percent / PbO₂ / benzene / 20 °C

With triethylsilane; lithium aluminium tetrahydride; oxalyl dichloride; lead dioxide; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; benzene; 2.2: Friedel-Crafts cyclization / 3.1: Stille coupling;
DOI:10.1016/S0040-4039(01)01564-7