15250-46-1

Basic information

• Product Name: 4-IODOPHENYLACETIC ACID ETHYL ESTER
• Synonyms: ETHYL 4-IODPHENYLACETATE;4-IODOPHENYLACETIC ACID ETHYL ESTER;Ethyl (4-Iodophenyl)acetate;Benzeneacetic acid, 4-iodo-, ethyl ester;Ethyl 2-(4-iodophenyl)acetate;Ethyl 2-(4-iodophenyl)
• CAS NO: 15250-46-1
• Molecular Formula: C₁₀H₁₁IO₂
• Molecular Weight: 290.1
• Product Categories: Esters;Phenyls & Phenyl-Het
• Mol File: 15250-46-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 288.637 °C at 760 mmHg
• Flash Point: 128.363 °C
• Appearance: /
• Density: 1.604 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4-IODOPHENYLACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODOPHENYLACETIC ACID ETHYL ESTER(15250-46-1)
• EPA Substance Registry System: 4-IODOPHENYLACETIC ACID ETHYL ESTER(15250-46-1)

Safety Data

• Hazardous Substances Data: 15250-46-1(Hazardous Substances Data)

Usage

General Description

4-IODOPHENYLACETIC ACID ETHYL ESTER is a chemical compound with the molecular formula C10H11IO2. It is an ethyl ester derivative of 4-iodophenylacetic acid, and is commonly used in organic synthesis and pharmaceutical research. 4-IODOPHENYLACETIC ACID ETHYL ESTER is a pale yellow solid with a melting point of 83-86°C, and it is soluble in organic solvents such as ethanol and ether. It is primarily used as an intermediate in the synthesis of various pharmaceuticals and biologically active compounds. Additionally, 4-IODOPHENYLACETIC ACID ETHYL ESTER is also used in the production of pesticides and other agrochemicals. However, it is important to handle this compound with caution, as it is a potentially hazardous chemical and should be used in a controlled laboratory setting with proper safety equipment.

Upstream product

• 14062-25-0 Ethyl 4-bromophenylacetate 
• 5438-70-0 ethyl (4-amino-3,5-dibromophenyl)acetate 
• 64-17-5 ethanol 
• 1798-06-7 (4-iodophenyl)acetic acid 
• 623-73-4 diazoacetic acid ethyl ester 
• 1338250-05-7 dimethyl 4-iodophenylboronate 
• 5122-99-6 4-iodophenylboronic acid 
• 623-33-6 glycine ethyl ester hydrochloride 

Downstream Products

• 403508-26-9 3-(3,6-di-tert-butyl-2,7-dimethoxy-naphthalen-1-yl)-3-hydroxy-2-(4-iodo-phenyl)-propionic acid ethyl ester 
• 859168-30-2 4-(4-iodo-phenyl)-2H-isoxazol-5-one 
• 92021-94-8 (4-iodo-phenyl)-malonic acid diethyl ester 
• 135569-28-7 1-(p-iodophenyl)cyclopentanecarboxylic acid 
• 14062-23-8 4-biphenylylacetic acid ethyl ester 
• 1308917-78-3 C₂₉H₃₇N₅O₄Si 
• 1308917-80-7 2-{4-[7-amino-8-ethyl-5-oxo-6-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-5,8-dihydro-1,8-naphthyridin-2-yl]phenyl}-N-[(4-cyclopropylmorpholin-3-yl)methyl]acetamide 
• 1308917-77-2 (4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid 

Relevant articles and documents

BIARYL COMPOUND, PREPARATION METHOD AND USE THEREFOR

The present invention belongs to the technical field of chemical pharmaceuticals, and relates to a compound represented by general formula (I) or formula (II) and a preparation method thereof. The compounds are biaryl derivatives with RORγt activation activity. The biaryl derivatives disclosed in this invention can effectively activate the RORγt protein receptor, and thereby promote the differentiation of Th17 cells and increasing the production of IL-17, which can be used as an immune modulator for the treatment of various cancers or viral infection-related diseases.

Synthesis of α-aryl esters and nitriles: Deaminative coupling of α-aminoesters and α-aminoacetonitriles with arylboronic acids

Transition-metal-free synthesis of α-aryl esters and nitriles using arylboronic acids with α-aminoesters and α-aminoacetonitriles, respectively, as the starting materials has been developed. The reaction represents a rare case of converting C(sp3)-N bonds into C(sp3)-C(sp2) bonds. The reaction conditions are mild, demonstrate good functional-group tolerance, and can be scaled up. Touch base: A transition-metal-free protocol for the synthesis of α-aryl esters and nitriles by deaminative coupling is presented. Strong bases and transition-metal catalysts are not needed. The new synthetic method uses readily available starting materials and demonstrates wide substrate scope.

DERIVATIVES OF 1-PHENYL-1,5-DIHYDRO-BENZO[B] [1.4]DIAZEPINE-2.4-DIONE AS INHIBITORS OF HIV REPLICATION

Compounds of formula (I) wherein m, R1, R2, R3, X and Y are defined herein, are useful as inhibitors of HIV replication.