tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl}acetate

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Chemical Name:tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl}acetate
CAS No.:1598386-22-1
Molecular Formula:C₂₈H₄₄N₄O₇
Molecular Weight:548.68
Hs Code.:

Synonyms:tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl}acetate

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Chemical Property of tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl}acetate

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Technology Process of tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl}acetate

There total 4 articles about tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.2%

: 1598386-21-0
1-bromo-4-(4-nitrophenyl)butan-2-one

: 174137-97-4
1,4-bis(tert-butoxycarbonylmethyl)-1,4,7-triazacyclononane

: 1598386-22-1
tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl}acetate

Guidance literature:: With hydrogenchloride; triethylamine; sodium hydroxide; In acetonitrile; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.bmc.2014.02.041

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1598386-22-1
tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 2.5 h

2: hydrogenchloride; acetic acid / water / 24 h / Reflux

3: bromine / methanol / 35 h / 7 - 9 °C

4: hydrogenchloride; sodium hydroxide; triethylamine / acetonitrile / 24 h / 0 - 20 °C

With hydrogenchloride; bromine; sodium hydride; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1016/j.bmc.2014.02.041

Reference yield:

: 30780-19-9
4-(4-nitrophenyl)butan-2-one

: 1598386-22-1
tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: bromine / methanol / 35 h / 7 - 9 °C

2: hydrogenchloride; sodium hydroxide; triethylamine / acetonitrile / 24 h / 0 - 20 °C

With hydrogenchloride; bromine; triethylamine; sodium hydroxide; In methanol; acetonitrile;
DOI:10.1016/j.bmc.2014.02.041