4-(4-BOC-aminobutylcarbamoyl)-2-nitrobenzylic alcohol

Base Information

• Chemical Name: 4-(4-BOC-aminobutylcarbamoyl)-2-nitrobenzylic alcohol
• CAS No.: 508234-74-0
• Molecular Formula: C₁₇H₂₅N₃O₆
• Molecular Weight: 367.402
• Mol file: 508234-74-0.mol

Synonyms:4-(4-BOC-aminobutylcarbamoyl)-2-nitrobenzylic alcohol

Chemical Property of 4-(4-BOC-aminobutylcarbamoyl)-2-nitrobenzylic alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-BOC-aminobutylcarbamoyl)-2-nitrobenzylic alcohol

There total 2 articles about 4-(4-BOC-aminobutylcarbamoyl)-2-nitrobenzylic alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-amino-4-[(tert-butyloxycarbonyl)amino]butane (68076-36-8) + 4-(hydroxymethyl)-3-nitrobenzoic acid (82379-38-2) → 4-(4-BOC-aminobutylcarbamoyl)-2-nitrobenzylic alcohol (508234-74-0)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; for 2h;

DOI:10.1016/S0968-0896(02)00311-5

Reference yield:

4-bromomethyl-3-nitrobenzoic acid (55715-03-2) → 4-(4-BOC-aminobutylcarbamoyl)-2-nitrobenzylic alcohol (508234-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / aq. Na₂CO₃ / acetone / 5 h / Heating

2: 59 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / ethanol / 2 h

With sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; acetone;

DOI:10.1016/S0968-0896(02)00311-5

Reference yield: 81.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 4-(4-BOC-aminobutylcarbamoyl)-2-nitrobenzylic alcohol (508234-74-0) → (4-{4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxymethyl]-3-nitro-benzoylamino}-butyl)-carbamic acid tert-butyl ester (508234-75-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

DOI:10.1016/S0968-0896(02)00311-5

upstream raw materials:

1-amino-4-[(tert-butyloxycarbonyl)amino]butane

4-(hydroxymethyl)-3-nitrobenzoic acid

4-bromomethyl-3-nitrobenzoic acid

Downstream raw materials:

(4-{4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxymethyl]-3-nitro-benzoylamino}-butyl)-carbamic acid tert-butyl ester

[4-(4-{(2-Cyano-ethoxy)-[(3aR,4R,6R,6aR)-6-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-phosphoryloxymethyl}-3-nitro-benzoylamino)-butyl]-carbamic acid tert-butyl ester

C₅₁H₇₅N₁₂O₁₈P

Refernces