82379-38-2

Usage

Uses

Used in Pharmaceutical Industry:
4-HYDROXYMETHYL-3-NITROBENZOIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its versatile chemical properties and reactivity. It contributes to the development of new drugs with potential therapeutic applications.
Used in Fine Chemicals Industry:
4-HYDROXYMETHYL-3-NITROBENZOIC ACID is utilized as a building block in the production of fine chemicals, taking advantage of its unique structural features and chemical reactivity to create specialty compounds for various applications.
Used in Agrochemicals Industry:
4-HYDROXYMETHYL-3-NITROBENZOIC ACID is employed as a starting material or intermediate in the formulation of agrochemicals, such as pesticides and herbicides, due to its potential to enhance the effectiveness and selectivity of these products.
Used in Industrial Chemicals:
4-HYDROXYMETHYL-3-NITROBENZOIC ACID is used in the development of other industrial chemicals, leveraging its unique structural features and reactivity to create compounds with specific properties for various applications in industries such as plastics, coatings, and dyes.

InChI:InChI=1/C8H7NO5/c10-4-6-2-1-5(8(11)12)3-7(6)9(13)14/h1-3,10H,4H2,(H,11,12)

Upstream product

• 55715-03-2 4-bromomethyl-3-nitrobenzoic acid 
• 6232-88-8 4-bromomethylbenzoic Acid 
• 89950-93-6 methyl 4-(hydroxymethyl)-3-nitrobenzoate 

Downstream Products

• 130581-93-0 4-(Hydroxymethyl)-3-nitrobenzoic acid 2,4,5-trichlorophenyl ester 
• 89950-93-6 methyl 4-(hydroxymethyl)-3-nitrobenzoate 
• 666848-42-6 3-nitro-4-trityloxymethyl-benzoic acid 
• 508234-75-1 (4-{4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxymethyl]-3-nitro-benzoylamino}-butyl)-carbamic acid tert-butyl ester 
• 508234-76-2 [4-(4-{(2-Cyano-ethoxy)-[(3aR,4R,6R,6aR)-6-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-phosphoryloxymethyl}-3-nitro-benzoylamino)-butyl]-carbamic acid tert-butyl ester 
• 508234-89-7 C₅₁H₇₅N₁₂O₁₈P 
• 959697-95-1 4-carboxy-2-nitrobenzyl isonicotinate 
• 959697-96-2 4-[N-(3-triethoxysilyl)propyl]-carbamoyl-2-nitrobenzyl isonicotinate 
• 1616470-87-1 C₁₁H₁₀N₂O₄ 

Relevant academic research and scientific papers

Dual system for the central nervous system targeting and blood-brain barrier transport of a selective prolyl oligopeptidase inhibitor

Less than 2% of all potential neurotherapeutics cross the blood-brain barrier (BBB). Here, we sought to build a construct with the capacity to cross this barrier, to behave as a chemical delivery system, and, once inside the central nervous system, to be

Photocontrolled Multidirectional Differentiation of Mesenchymal Stem Cells on an Upconversion Substrate

The effective guidance of mesenchymal stem cell (MSC) differentiation on a substrate by near-infrared (NIR) light is particularly attractive for tissue engineering and regenerative medicine. However, most of current substrates cannot control multidirectio

Dual Stimuli-Responsive Block Copolymers with Adjacent Redox- And Photo-Cleavable Linkages for Smart Drug Delivery

A novel dual-stimuli cleavable linker containing adjacent UV light-sensitive o-nitrobenzyl ester and GSH-responsive disulfide bonds was first designed and synthesized to increase the responsivity to external stimuli. The functionalized linker was then uti

Near-infrared upconversion controls photocaged cell adhesion

Dynamic control of cell-surface interactions with near-infrared (NIR) light is particularly attractive for regeneration medicine and cell-based therapy. Herein we successfully achieve NIR-controlled cell adhesion with upconversion nanoparticles (UCNPs) ba

Photo-Cleavable Surfactants

The present invention provides photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded upon UV irradiation, for top-down and bottom-up proteomics. These surfactants can effectively solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis of the solubilized proteins and peptide fragments. Top-down proteomic studies using the present photo-cleavable anionic surfactants has allowed the detection of 100-fold more unique proteoforms as compared to controls and has enabled the solubilization of membrane proteins for comprehensive characterization of protein post-trans-modifications. In addition, the present photo-cleavable anionic surfactants are also suitable for dissolving polypeptides in bottom-up proteomic experiments including extracellular matrix proteomics, and are suitable as a substitute for SDS in gel electrophoresis.

Non-natural amino acid and application thereof in protein site-specific modification and protein interaction

The invention relates to a non-natural amino acid compound represented by a general formula (I) and a preparation method thereof, and applications of the non-natural amino acid compound in fixed-pointmodification of bio-macro-molecular proteins, protein i

Photo-induced multifunctional cross-linking agent, preparation method and application thereof

The invention relates to a photo-induced multifunctional cross-linking agent as shown in a general formula (I), wherein the photo-induced multifunctional cross-linking agent is mainly applied to biomacromolecule interaction, such as protein-protein interaction and protein-nucleic acid interaction. According to the invention, the cross-linking agent can be used in biological samples or cells of cell lysis solutions to capture protein-protein interaction or protein-nucleic acid interaction, and can be applied to subsequent protein enrichment and protein cross-linking mass spectrometry; and the photo-induced multifunctional cross-linking agent has important application potential and practical value in interaction research of biomacromolecules.

O-nitrobenzyl liposomes with dual-responsive release capabilities for drug delivery

To improve the therapeutic efficacy of anticancer drugs and reduce its toxic side effects, we synthesized a series of amphiphilic o-nitrobenzyl molecules 4-(4-N,N,N,N-dicarboxymethyl-diethylenetriamino)acetoxymethyl-3-nitro-N,N-dialk-ylbenzamide (N,N-NB-DTPA) with good photolysis property and acid sensitivity. Simultaneously, N, N-NB-DTPA liposomes composed of the o-nitrobenzyl molecules have good biocompatibility, low hemolysis rate and cytotoxicity, and the drug encapsulation efficiency of the liposomes exceeds 70%. N, N-NB-DTPA-DOX liposomes possess good stability and can keep uniform distribution in PBS solution for 10 days. The drug release rate of these drug-loaded liposomes reaches to the maximums under pH 5.0 and 30 min UV irradiation, revealing pH/UV dual-responsiveness of these drug-loaded liposomes. The low pH makes DOX separate from these drug-loaded liposomes, and the UV irradiation leads to o-nitrobenzyl ester bond cleave, which contribute to accelerate the release of drug from drug-loaded liposomes. Furthermore, N, N-NB-DTPA-DOX liposomes after UV irradiation have better therapeutic effect than single DOX·HCl, which may result from the production of nitrosobenzaldehyde derivatives after UV irradiation.

PROGRAMMABLE THERMORESPONSIVE GELS

Provided herein, inter alia, are non-crosslinked polymers that possess thermoresponsive properties. These polymers possess a cleavable bond that breaks under certain conditions The disclosure also provides pharmaceutical compositions containing the polyme

Multi-stimuli controlled release of a transmembrane chloride ion carrier from a sulfonium-linked procarrier

In recent times, anion transporters have received substantial consideration due to their ability to disrupt the ionic equilibrium across membrane bilayers. While numerous Cl- ion transporters were developed for channelopathies, unfortunately, poor aqueous solubility precluded their bioapplicability. Herein, we demonstrate the development of a multi-stimuli activatable anion transport approach to induce regulated transport of Cl- ions across membranes under specific conditions. The sulfonium-based procarrier was initially inactive, but the transmembrane transport of Cl- ions was activated in the presence of stimuli such as glutathione (GSH), reactive oxygen species (ROS) and light. The release of the hydrophobic anionophore from the aqueous-soluble procarrier under specific conditions leads to the successful transport of Cl- ions. Under physiological conditions, these anion carriers follow an antiport exchange mechanism to transport Cl- ions across lipid bilayers. Such multi-stimuli activatable procarriers have great potential to combat various types of channelopathies, including cancer, cystic fibrosis, kidney stones, myotonia, and others.