3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbaldehyde

Base Information

Chemical Name:3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbaldehyde
CAS No.:163562-10-5
Molecular Formula:C₂₀H₁₉NO₃S
Molecular Weight:353.442
Hs Code.:

3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benz<e>indole-8-carbaldehyde

Synonyms:3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbaldehyde

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Chemical Property of 3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbaldehyde

Chemical Property:

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Technology Process of 3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbaldehyde

There total 2 articles about 3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 163562-09-2
3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbonitrile

: 163562-10-5
3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jm00012a022

Reference yield:

: 155591-01-8
3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one

: 163562-10-5
3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LiCN, 2.) Sm, diiodoethane / 1.) THF, 30 min, 2.) THF, t-BuOH, 1 h

2: 82 percent / diisobutylaluminum hydride / CH₂Cl₂ / 2 h / 0 °C

With samarium; 1,1-diiodoethane; lithium cyanide; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1021/jm00012a022

Reference yield:

: 163562-10-5
3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbaldehyde

: (3-Phenyl-propyl)-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-ylmethyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) acetic acid, 2.) NaCNBH₃ / 1.) MeOH, THF, 30 min, 2.) MeOH, THF, RT, 16 h

2: 80 percent / CH₃ONa / tetrahydrofuran; methanol / Heating

With sodium methylate; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jm00012a022