trifluoro-methanesulfonic acid 3-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-iodo-4-methyl-benzyl]-2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl ester

Base Information

Chemical Name:trifluoro-methanesulfonic acid 3-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-iodo-4-methyl-benzyl]-2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl ester
CAS No.:887142-50-9
Molecular Formula:C₂₆H₂₅F₃INO₆S
Molecular Weight:663.453
Hs Code.:

trifluoro-methanesulfonic acid 3-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-iodo-4-methyl-benzyl]-2,2,6,6-tetramethyl-3,6-dihydro-2<i>H</i>-pyran-4-yl ester

Synonyms:trifluoro-methanesulfonic acid 3-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-iodo-4-methyl-benzyl]-2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl ester

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Chemical Property of trifluoro-methanesulfonic acid 3-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-iodo-4-methyl-benzyl]-2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl ester

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Technology Process of trifluoro-methanesulfonic acid 3-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-iodo-4-methyl-benzyl]-2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl ester

There total 10 articles about trifluoro-methanesulfonic acid 3-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-iodo-4-methyl-benzyl]-2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 887142-49-6
2-[4-Iodo-2-methyl-5-((R)-2,2,6,6-tetramethyl-4-oxo-tetrahydro-pyran-3-ylmethyl)-phenyl]-isoindole-1,3-dione

: 145100-51-2
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

: 887142-50-9
trifluoro-methanesulfonic acid 3-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-iodo-4-methyl-benzyl]-2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl ester

Guidance literature:: 2-[4-Iodo-2-methyl-5-((R)-2,2,6,6-tetramethyl-4-oxo-tetrahydro-pyran-3-ylmethyl)-phenyl]-isoindole-1,3-dione; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide; In tetrahydrofuran; at -78 - -25 ℃;
DOI:10.1021/ol0602912

Reference yield:

: 85-44-9
phthalic anhydride

: 887142-50-9
trifluoro-methanesulfonic acid 3-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-iodo-4-methyl-benzyl]-2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / toluene / 3.5 h / Heating

2.1: 90 percent / HCl / tetrahydrofuran; H₂O / 2 h / 24 °C

3.1: 85 percent / phosphorous tribromide / CH₂Cl₂ / 0.25 h / 0 - 25 °C

4.1: tert-butyllithium / tetrahydrofuran; pentane / 2.5 h / -78 °C

4.2: 72 percent / tetrahydrofuran; pentane / 1.5 h / -105 - -78 °C

5.1: ozone / CH₂Cl₂ / 0.25 h / -78 °C

5.2: 74 percent / dimethyl sulfide / CH₂Cl₂ / 2 h / -78 - 20 °C

6.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

6.2: 82 percent / tetrahydrofuran / 2.25 h / -78 °C

With hydrogenchloride; tert.-butyl lithium; phosphorus tribromide; ozone; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; toluene; pentane;
DOI:10.1021/jo062422i

Reference yield:

: 944262-95-7
2-(4-Iodo-5-{(S)-4-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-2,2,6,6-tetramethyl-tetrahydro-pyran-3-ylmethyl}-2-methyl-phenyl)-isoindole-1,3-dione

: 887142-50-9
trifluoro-methanesulfonic acid 3-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-iodo-4-methyl-benzyl]-2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / CH₂Cl₂ / 0.25 h / -78 °C

1.2: 74 percent / dimethyl sulfide / CH₂Cl₂ / 2 h / -78 - 20 °C

2.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

2.2: 82 percent / tetrahydrofuran / 2.25 h / -78 °C

With ozone; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo062422i