944262-95-7Relevant academic research and scientific papers
Indole diterpene synthetic studies. Total synthesis of (+)-nodulisporic acid F and construction of the heptacyclic cores of (+)-nodulisporic acids A and B and (-)-nodulisporic acid D
Smith III, Amos B.,Davulcu, Akin H.,Young, Shin Cho,Ohmoto, Kazuyuki,Kuerti, Laszlo,Ishiyama, Haruaki
, p. 4596 - 4610 (2008/02/05)
(Chemical Equation Presented) A first-generation strategy for construction of (+)-nodulisporic acids A (1) and B (2) is described. The strategy entails union of the eastern and western hemisphere subtargets via the indole synthesis protocol developed in our laboratory. Subsequent elaboration of rings E and F, however, revealed the considerable acid instability of the C(24) hydroxyl, thereby preventing further advancement. Nonetheless, preparation of the heptacyclic core of (+)-nodulisporic acids A and B, the total synthesis of (+)-nodulisporic acid F, the simplest member of the nodulisporic acid family, and elaboration of the heptacyclic core of (-)-nodulisporic acid D were achieved.
Indole diterpenoid synthetic studies. Construction of the heptacyclic core of (-)-nodulisporic acid D
Smith III, Amos B.,Davulcu, Akin H.,Kuerti, Laszlo
, p. 1669 - 1672 (2007/10/03)
Construction of the heptacyclic core of (-)-nodulisporic acid D, a representative member of a recently discovered class of architecturally complex, ectoparasiticidal indole alkaloids, has been achieved. The modular synthetic strategy comprises an expedien
