1-(Benzyloxy)-4-ethynyl-2-methoxybenzene

Base Information

• Chemical Name: 1-(Benzyloxy)-4-ethynyl-2-methoxybenzene
• CAS No.: 144735-54-6
• Molecular Formula: C16H14 O2
• Molecular Weight: 238.286
• DSSTox Substance ID: DTXSID50448892
• Nikkaji Number: J1.365.344E
• Wikidata: Q82268086
• Mol file: 144735-54-6.mol

Synonyms:144735-54-6;1-(BENZYLOXY)-4-ETHYNYL-2-METHOXYBENZENE;4-ethynyl-2-methoxy-1-phenylmethoxybenzene;4-BENZYLOXY-1-ETHYNYL-3-METHOXY-BENZENE;Benzene, 4-ethynyl-2-methoxy-1-(phenylmethoxy)-;2-(Benzyloxy)-5-ethynylanisole;DTXSID50448892;4-benzyloxy-3-methoxyphenylacetylene;4-benzyloxy-1-ethynyl-3-methoxybenzene;CS-0237776;EN300-1869207;A1-24005

Chemical Property of 1-(Benzyloxy)-4-ethynyl-2-methoxybenzene

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.586
• Boiling Point: 359.584°C at 760 mmHg
• Flash Point: 142.342°C
• PSA: 18.46000
• Density: 1.122g/cm³
• LogP: 3.25550
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 238.099379685
• Heavy Atom Count: 18
• Complexity: 285

Purity/Quality:

97% ^*data from raw suppliers

4-BENZYLOXY-1-ETHYNYL-3-METHOXY-BENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)C#C)OCC2=CC=CC=C2

Technology Process of 1-(Benzyloxy)-4-ethynyl-2-methoxybenzene

There total 7 articles about 1-(Benzyloxy)-4-ethynyl-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(benzyloxy)-4-(2,2-dibromoethene)-2-methoxybenzene → 1-ethynyl-4-(benzyloxy)-3-methoxybenzene (144735-54-6)

Guidance literature:

With ethylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2009.03.061

Reference yield: 92.0%

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) + carbon tetrabromide (558-13-4) → 1-ethynyl-4-(benzyloxy)-3-methoxybenzene (144735-54-6)

Guidance literature:

3-methoxy-4-(phenylmethoxy)benzaldehyde; carbon tetrabromide; With triisopropyl phosphite; In acetonitrile; at 0 ℃; for 0.166667h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In acetonitrile; at 0 - 20 ℃; for 4h;

DOI:10.1002/adsc.201801334

Reference yield: 79.0%

β-(3-methoxy-4-(benzyloxy)phenyl)-β-chloracrolein (144735-53-5) → 1-ethynyl-4-(benzyloxy)-3-methoxybenzene (144735-54-6)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 80 ℃; for 2h;

DOI:10.1021/jo00052a046

upstream raw materials:

β-(3-methoxy-4-(benzyloxy)phenyl)-β-chloracrolein

4-benzyloxy-3-methoxyacetophenone

benzyl bromide

1-(3-methoxy-4-hydroxyphenyl)ethanone

Downstream raw materials:

5-(2-(methoxycarbonyl)trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-(benzyloxy)phenyl)benzofuran

5-(2-(ethoxycarbonyl)-E-ethenyl)-7-methoxy-2-(3-methoxy-4-benzyloxyphenyl)benzofuran

5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo[b]furan-carbaldehyde

2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 144735-54-6 4-BENZYLOXY-1-ETHYNYL-3-METHOXY-BENZENE

Send

Send

Metric Ton KG G Pound L ML

Send

Send