3-(3-{4-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]but-1-ynyl}phenyl)imidazolidine-2,4-dione

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Chemical Name:3-(3-{4-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]but-1-ynyl}phenyl)imidazolidine-2,4-dione
CAS No.:457644-49-4
Molecular Formula:C₃₁H₃₉N₃O₆
Molecular Weight:549.667
Hs Code.:

Synonyms:3-(3-{4-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]but-1-ynyl}phenyl)imidazolidine-2,4-dione

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Chemical Property of 3-(3-{4-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]but-1-ynyl}phenyl)imidazolidine-2,4-dione

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Technology Process of 3-(3-{4-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]but-1-ynyl}phenyl)imidazolidine-2,4-dione

There total 5 articles about 3-(3-{4-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]but-1-ynyl}phenyl)imidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 208925-08-0
(2R)-hydroxy-2-(2,2-dimethyl-4H-1,3-benzodioxine-6-yl)-ethylamine

: 102294-98-4
1-bromo-6-[(3-butynyl)oxy]hexane

: 457635-26-6
3-(3-iodophenyl)imidazolidine-2,4-dione

: 457644-49-4
3-(3-{4-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]but-1-ynyl}phenyl)imidazolidine-2,4-dione

Guidance literature:: 1-bromo-6-[(3-butynyl)oxy]hexane; 3-(3-iodophenyl)imidazolidine-2,4-dione; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h; Inert atmosphere;

(2R)-hydroxy-2-(2,2-dimethyl-4H-1,3-benzodioxine-6-yl)-ethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 22h;
DOI:10.1016/j.bmc.2011.05.064

Reference yield:

: 457635-17-5
ethyl N-{[(3-iodophenyl)amino]carbonyl}glycinate

: 457644-49-4
3-(3-{4-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]but-1-ynyl}phenyl)imidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / Inert atmosphere

2.2: 22 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; mineral oil; 2.1: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.064

Reference yield:

: 626-01-7
3-Iodoaniline

: 457644-49-4
3-(3-{4-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]but-1-ynyl}phenyl)imidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 2 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / Inert atmosphere

3.2: 22 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil; 3.1: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.064