(R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester

Base Information

Chemical Name:(R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester
CAS No.:444901-95-5
Molecular Formula:C₂₃H₂₉N₂O₃PS
Molecular Weight:444.535
Hs Code.:

Synonyms:(R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester

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Chemical Property of (R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester

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Technology Process of (R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester

There total 5 articles about (R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 4070-48-8,18869-42-6,21685-47-2
D-Valine methyl ester

: 61057-98-5
(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid

: 444901-95-5
(R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1016/S0040-4039(02)00346-5

Reference yield:

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 444901-95-5
(R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / toluene / 20 °C

2: S₈ / toluene / 20 °C

3: 88 percent / lithium iodide / pyridine / 145 - 150 °C

4: 68 percent / EDC; HOBT / CH₂Cl₂ / 20 °C

With sulfur; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; lithium iodide; In pyridine; dichloromethane; toluene;
DOI:10.1016/S0040-4039(02)00346-5

Reference yield:

: (S)-1-Diphenylphosphanyl-pyrrolidine-2-carboxylic acid benzyl ester

: 444901-95-5
(R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: S₈ / toluene / 20 °C

2: 88 percent / lithium iodide / pyridine / 145 - 150 °C

3: 68 percent / EDC; HOBT / CH₂Cl₂ / 20 °C

With sulfur; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium iodide; In pyridine; dichloromethane; toluene;
DOI:10.1016/S0040-4039(02)00346-5