61057-98-5

Upstream product

• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 41324-66-7 H-Pro-OBzl 
• 608533-81-9 diphenylphosphine proline methyl ester 
• 1079-66-9 chloro-diphenylphosphine 
• 282088-13-5 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 444901-94-4 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid benzyl ester 

Downstream Products

• 444901-95-5 (R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester 
• 444901-96-6 (R)-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-phenyl-acetic acid methyl ester 
• 666723-36-0 (R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3,3-dimethyl-butyric acid 
• 444901-97-7 (R)-2-[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4-isopropyl-4,5-dihydro-oxazole 
• 444901-99-9 (S)-2-[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4-isopropyl-4,5-dihydro-oxazole 
• 666727-83-9 (R)-4-tert-Butyl-2-[(S)-1-(diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4,5-dihydro-oxazole 
• 608533-93-3 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid ((R)-1-hydroxymethyl-2-methyl-propyl)-amide 
• 444901-98-8 (R)-2-[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4-phenyl-4,5-dihydro-oxazole 

Relevant academic research and scientific papers

Two-fold amino acid-based chiral aminophosphine-oxazolines and use in asymmetric allylic alkylation

Chiral aminophosphine-oxazoline ligands derived from two different amino acids (tetrahydroisoquinoline carboxylic acid and proline) have been synthesized and examined as chiral auxiliaries in asymmetric allylic alkylation of three substrates. Stereoisomers 1a and 2a are providing the highest enantioselectivities (up to 94% ee) in the allylation of diphenylpropenyl acetate.

Asymmetric hydrogenation of aromatic olefins catalyzed by iridium complexes of proline derived phosphine-oxazoline ligands

The synthesis of a series of phosphine-oxazoline ligands is reported. This ligands are synthesized by reaction of a phosphine chloride with the secondary nitrogen of proline. Upon coordination to iridium the resulting complexes can be used in the asymmetric hydrogenation of simple olefins. The effect of different counter ions and substitution at the oxazoline and the phosphine is reported.

Facile synthesis of proline based phosphine-oxazoline ligands by formation of a P-N bond

A series of new P-N ligands in which the phosphorus moiety is introduced by formation of a phosphorus-heteroatom bond are synthesized. These ligands are based on proline with chiral centers from both proline and an oxazoline. The two chiral centers are re