(S)-methyl 2-<(tert-butoxycarbonyl)amino>-3-<(p-methoxyphenyl)thio>propiolate

Base Information

Chemical Name:(S)-methyl 2-<(tert-butoxycarbonyl)amino>-3-<(p-methoxyphenyl)thio>propiolate
CAS No.:172882-75-6
Molecular Formula:C₁₆H₂₃NO₅S
Molecular Weight:341.428
Hs Code.:

Synonyms:(S)-methyl 2-<(tert-butoxycarbonyl)amino>-3-<(p-methoxyphenyl)thio>propiolate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 2-<(tert-butoxycarbonyl)amino>-3-<(p-methoxyphenyl)thio>propiolate

Chemical Property:

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Technology Process of (S)-methyl 2-<(tert-butoxycarbonyl)amino>-3-<(p-methoxyphenyl)thio>propiolate

There total 1 articles about (S)-methyl 2-<(tert-butoxycarbonyl)amino>-3-<(p-methoxyphenyl)thio>propiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 696-63-9
4-Methoxybenzenethiol

: 126645-21-4
methyl N-(tert-butoxycarbonyl)-O-[(4-methylphenyl)sulfonyl]-D-serinate

: 172882-75-6
(S)-methyl 2-<(tert-butoxycarbonyl)amino>-3-<(p-methoxyphenyl)thio>propiolate

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 2 h;
DOI:10.1021/jm950576c

Reference yield: 99.0%

: 172882-75-6
(S)-methyl 2-<(tert-butoxycarbonyl)amino>-3-<(p-methoxyphenyl)thio>propiolate

: 172882-73-4
(S)-2-<(tert-butoxycarbonyl)amino>-3-<(p-methoxyphenyl)thio>propionic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; for 8h; Ambient temperature;
DOI:10.1021/jm950576c

Reference yield:

: 172882-75-6
(S)-methyl 2-<(tert-butoxycarbonyl)amino>-3-<(p-methoxyphenyl)thio>propiolate

: 172882-84-7
2-{(2R,3S)-3-[(S)-2-Amino-3-(4-methoxy-phenylsulfanyl)-propionylamino]-2-hydroxy-4-phenyl-butyl}-N-tert-butyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / 0.5 M aq. LiOH / dioxane / 8 h / Ambient temperature

2: 55 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / dimethylformamide; tetrahydrofuran / a) 0 deg C, 2 h, b) RT, overnight

3: 94 percent / CF₃COOH / CH₂Cl₂ / 3 h / Ambient temperature

With lithium hydroxide; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950576c