N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-3,4,5-trimethoxybenzamide

Base Information

Chemical Name:N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-3,4,5-trimethoxybenzamide
CAS No.:1609574-73-3
Molecular Formula:C₁₉H₂₁F₂N₃O₈
Molecular Weight:457.388
Hs Code.:

Synonyms:N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-3,4,5-trimethoxybenzamide

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Chemical Property of N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-3,4,5-trimethoxybenzamide

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Technology Process of N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-3,4,5-trimethoxybenzamide

There total 4 articles about N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-3,4,5-trimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1254062-21-9
4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 1609574-73-3
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-3,4,5-trimethoxybenzamide

Guidance literature:: 4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one; 3,4,5-Trimethoxybenzoyl chloride; With pyridine; at 20 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield:

: 1609574-86-8
C₃₁H₄₇F₂N₃O₉Si₂

: 1609574-73-3
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-3,4,5-trimethoxybenzamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1016/j.ejmech.2020.113135

Reference yield:

: 95058-81-4,103882-85-5
gemcitabine

: 1609574-73-3
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-3,4,5-trimethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 48 h / 20 °C

2: pyridine / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2020.113135