4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one

Base Information

Chemical Name:4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one
CAS No.:1254062-21-9
Molecular Formula:C₂₁H₃₇F₂N₃O₅Si₂
Molecular Weight:505.71
Hs Code.:

Synonyms:4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one

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Chemical Property of 4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one

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Technology Process of 4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one

There total 1 articles about 4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 18043-71-5
1,1,3,3-tetraisopropyldisiloxane

: 122111-03-9
gemcitabine hydrochloride

: 1254062-21-9
4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one

Guidance literature:: gemcitabine hydrochloride; With pyridine;

1,1,3,3-tetraisopropyldisiloxane; at 100 - 120 ℃; for 17h;

Reference yield: 80.0%

: 1254062-21-9
4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one

: 3-ethyl-1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)carbonyl-1H-imidazol-3-ium tetrafluoroborate

: (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxycarbonyl-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3,diyl)-2',2'-difluoro-2'-deoxycytidine

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 24h;
DOI:10.1002/cmdc.201900324

Reference yield: 62.0%

: 1254062-21-9
4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 1609574-73-3
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-3,4,5-trimethoxybenzamide

Guidance literature:: 4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one; 3,4,5-Trimethoxybenzoyl chloride; With pyridine; at 20 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1.5h;