22-benzyloxy-2,8,11,17-tetraoxa-5,14-diazabicyclo[16.3.1]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-4,15-dione

Base Information

• Chemical Name: 22-benzyloxy-2,8,11,17-tetraoxa-5,14-diazabicyclo[16.3.1]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-4,15-dione
• CAS No.: 867258-38-6
• Molecular Formula: C₂₃H₂₈N₂O₇
• Molecular Weight: 444.485

Synonyms:22-benzyloxy-2,8,11,17-tetraoxa-5,14-diazabicyclo[16.3.1]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-4,15-dione

Chemical Property of 22-benzyloxy-2,8,11,17-tetraoxa-5,14-diazabicyclo[16.3.1]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-4,15-dione

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Technology Process of 22-benzyloxy-2,8,11,17-tetraoxa-5,14-diazabicyclo[16.3.1]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-4,15-dione

There total 4 articles about 22-benzyloxy-2,8,11,17-tetraoxa-5,14-diazabicyclo[16.3.1]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-4,15-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

3,6-dioxa-1,8-diaminooctane (929-59-9,892154-56-2) + (2-benzyloxy-3-methoxycarbonylmethoxy-phenoxy)-acetic acid methyl ester (765915-42-2) → 22-benzyloxy-2,8,11,17-tetraoxa-5,14-diazabicyclo[16.3.1]docosa-1(21),18(22),19-triene-4,15-dione (867258-38-6)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 168h;

DOI:10.1055/s-2005-869968

Reference yield:

2-(phenylmethoxy)-1,3-benzenediol (55020-66-1) → 22-benzyloxy-2,8,11,17-tetraoxa-5,14-diazabicyclo[16.3.1]docosa-1(21),18(22),19-triene-4,15-dione (867258-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / butan-2-one

2: 54 percent / MeONa / methanol / 168 h / 20 °C

With sodium methylate; potassium carbonate; In methanol; butanone;

DOI:10.1055/s-2005-869968

Reference yield:

benzyl bromide (100-39-0) → 22-benzyloxy-2,8,11,17-tetraoxa-5,14-diazabicyclo[16.3.1]docosa-1(21),18(22),19-triene-4,15-dione (867258-38-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide

1.2: 33 percent / dimethylformamide

2.1: 90 percent / K₂CO₃ / butan-2-one

3.1: 54 percent / MeONa / methanol / 168 h / 20 °C

With sodium methylate; sodium hydride; potassium carbonate; In methanol; N,N-dimethyl-formamide; butanone;

DOI:10.1055/s-2005-869968

upstream raw materials:

3,6-dioxa-1,8-diaminooctane

(2-benzyloxy-3-methoxycarbonylmethoxy-phenoxy)-acetic acid methyl ester

2-(phenylmethoxy)-1,3-benzenediol

benzyl bromide

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