(S)-1-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-1-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester
CAS No.:177659-56-2
Molecular Formula:C₂₃H₃₄N₂O₅
Molecular Weight:418.533
Hs Code.:

Synonyms:(S)-1-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Property of (S)-1-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

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Technology Process of (S)-1-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

There total 4 articles about (S)-1-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 136092-78-9
(2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]pentanoic acid

: 41324-66-7
H-Pro-OBzl

: 177659-56-2
(S)-1-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: With bromo-tris-dimethylamino-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1016/0040-4020(96)00242-6

Reference yield:

: 19635-90-6
Z-(L)NMeNva

: 177659-56-2
(S)-1-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / ammonium formate / 10percent Pd/C / methanol / 4 h / Ambient temperature

2: 1 N NaOH / dioxane

3: 75 percent / BROP, DIEA / CH₂Cl₂ / 16 h / Ambient temperature

With sodium hydroxide; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/0040-4020(96)00242-6

Reference yield:

: (S)-3-Benzyl-4-propyl-oxazolidin-5-one

: 177659-56-2
(S)-1-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylsilane, TFA / CH₂Cl₂ / 20 h / Ambient temperature

2: 100 percent / ammonium formate / 10percent Pd/C / methanol / 4 h / Ambient temperature

3: 1 N NaOH / dioxane

4: 75 percent / BROP, DIEA / CH₂Cl₂ / 16 h / Ambient temperature

With triethylsilane; sodium hydroxide; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; ammonium formate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/0040-4020(96)00242-6