(R)-1-[4-((R)-2-Hydroxy-5-trimethylsilanyl-pent-4-ynyloxy)-phenoxy]-5-trimethylsilanyl-pent-4-yn-2-ol

Base Information

Chemical Name:(R)-1-[4-((R)-2-Hydroxy-5-trimethylsilanyl-pent-4-ynyloxy)-phenoxy]-5-trimethylsilanyl-pent-4-yn-2-ol
CAS No.:641613-66-3
Molecular Formula:C₂₂H₃₄O₄Si₂
Molecular Weight:418.681
Hs Code.:

Synonyms:(R)-1-[4-((R)-2-Hydroxy-5-trimethylsilanyl-pent-4-ynyloxy)-phenoxy]-5-trimethylsilanyl-pent-4-yn-2-ol

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Chemical Property of (R)-1-[4-((R)-2-Hydroxy-5-trimethylsilanyl-pent-4-ynyloxy)-phenoxy]-5-trimethylsilanyl-pent-4-yn-2-ol

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Technology Process of (R)-1-[4-((R)-2-Hydroxy-5-trimethylsilanyl-pent-4-ynyloxy)-phenoxy]-5-trimethylsilanyl-pent-4-yn-2-ol

There total 3 articles about (R)-1-[4-((R)-2-Hydroxy-5-trimethylsilanyl-pent-4-ynyloxy)-phenoxy]-5-trimethylsilanyl-pent-4-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1066-54-2
trimethylsilylacetylene

: 641613-65-2
C₁₂H₁₄O₄

: 641613-66-3
(R)-1-[4-((R)-2-Hydroxy-5-trimethylsilanyl-pent-4-ynyloxy)-phenoxy]-5-trimethylsilanyl-pent-4-yn-2-ol

Guidance literature:: With n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/j.tetlet.2003.09.141

Reference yield:

: 37592-20-4
1,4-bis(allyloxy)benzene

: 641613-66-3
(R)-1-[4-((R)-2-Hydroxy-5-trimethylsilanyl-pent-4-ynyloxy)-phenoxy]-5-trimethylsilanyl-pent-4-yn-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 66 percent / (dihydroquinine)2-phthalazine; aq. potassium ferricyanide; potassium osmate / K₂CO₃ / 2-methyl-propan-2-ol / 15 h / 0 °C

2.1: HBr; acetic acid / 1 h / 50 °C

2.2: 88 percent / K₂CO₃ / methanol / 4 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: BF₃*Et₂O / tetrahydrofuran; hexane / 0.33 h / -78 °C

3.3: tetrahydrofuran; hexane / 20 °C

With potassium osmate(VI); n-butyllithium; hydrogen bromide; acetic acid; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III); potassium carbonate; In tetrahydrofuran; hexane; tert-butyl alcohol;
DOI:10.1002/chem.200500892

Reference yield:

: 7734-54-5
3,3'-(1,4-phenylenebis(oxy))bis(propane-1,2-diol)

: 641613-66-3
(R)-1-[4-((R)-2-Hydroxy-5-trimethylsilanyl-pent-4-ynyloxy)-phenoxy]-5-trimethylsilanyl-pent-4-yn-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: HBr; acetic acid / 1 h / 50 °C

1.2: 88 percent / K₂CO₃ / methanol / 4 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: BF₃*Et₂O / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.3: tetrahydrofuran; hexane / 20 °C

With n-butyllithium; hydrogen bromide; acetic acid; In tetrahydrofuran; hexane;
DOI:10.1002/chem.200500892